Dynamic visualization of type II peptidyl carrier protein recognition in pyoluteorin biosynthesis†
Joshua C.
Corpuz, 
a
Larissa M.
Podust,
b
Tony D.
Davis,
a
Matt J.
Jaremko
a
and
Michael D.
Burkart
*a
a
Larissa M.
Podust,
b
Tony D.
Davis,
a
Matt J.
Jaremko
a
and
Michael D.
Burkart
*a
Abstract
Using a covalent chemical probe and X-ray crystallography coupled to nuclear magnetic resonance data, we elucidated the dynamic molecular basis of protein recognition between the carrier protein and adenylation domain in pyoluteorin biosynthesis. These findings reveal a unique binding mode, which contrasts previously solved carrier protein and partner protein interfaces.
- This article is part of the themed collection: Analytical methods in chemical biology
Please wait while we load your content...
