Issue 22, 2020

Materials promoting viral gene delivery

Abstract

Therapeutic viral gene delivery is an emerging technology which aims to correct genetic mutations by introducing new genetic information to cells either to correct a faulty gene or to initiate cell death in oncolytic treatments. In recent years, significant scientific progress has led to several clinical trials resulting in the approval of gene therapies for human treatment. However, successful therapies remain limited due to a number of challenges such as inefficient cell uptake, low transduction efficiency (TE), limited tropism, liver toxicity and immune response. To adress these issues and increase the number of available therapies, additives from a broad range of materials like polymers, peptides, lipids, nanoparticles, and small molecules have been applied so far. The scope of this review is to highlight these selected delivery systems from a materials perspective.

Graphical abstract: Materials promoting viral gene delivery

Article information

Article type
Review Article
Submitted
14 avq 2020
Accepted
27 sen 2020
First published
29 sen 2020
This article is Open Access
Creative Commons BY license

Biomater. Sci., 2020,8, 6113-6156

Materials promoting viral gene delivery

K. Kaygisiz and C. V. Synatschke, Biomater. Sci., 2020, 8, 6113 DOI: 10.1039/D0BM01367F

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