Issue 24, 2020

Biomaterial-based approaches to engineering immune tolerance

Abstract

The development of biomaterial-based therapeutics to induce immune tolerance holds great promise for the treatment of autoimmune diseases, allergy, and graft rejection in transplantation. Historical approaches to treat these immunological challenges have primarily relied on systemic delivery of broadly-acting immunosuppressive agents that confer undesirable, off-target effects. The evolution and expansion of biomaterial platforms has proven to be a powerful tool in engineering immunotherapeutics and enabled a great diversity of novel and targeted approaches in engineering immune tolerance, with the potential to eliminate side effects associated with systemic, non-specific immunosuppressive approaches. In this review, we summarize the technological advances within three broad biomaterials-based strategies to engineering immune tolerance: nonspecific tolerogenic agent delivery, antigen-specific tolerogenic therapy, and the emergent area of tolerogenic cell therapy.

Graphical abstract: Biomaterial-based approaches to engineering immune tolerance

Article information

Article type
Review Article
Submitted
14 iyl 2020
Accepted
05 noy 2020
First published
05 noy 2020

Biomater. Sci., 2020,8, 7014-7032

Biomaterial-based approaches to engineering immune tolerance

A. E. Emerson, E. M. Slaby, S. C. Hiremath and J. D. Weaver, Biomater. Sci., 2020, 8, 7014 DOI: 10.1039/D0BM01171A

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