Issue 7, 2020

Imaging mass spectrometry allows for neuroanatomic-specific detection of gangliosides in the healthy and diseased brain

Abstract

Gangliosides have a wide variety of biological functions due to their location on the outer leaflet of plasma membranes. They form a critical component of membrane rafts, or ganglioside-enriched microdomains, where they influence the physical properties of the membrane as well as its function. Gangliosides can change their structure to meet their external and internal environmental demands. This ability to change structure makes gangliosides both fascinating and technologically challenging targets to identify and understand. A full understanding on how gangliosides are regulated within the central nervous system (CNS) is critical, as ganglioside dysregulation is observed in the aging brain as well as in several neurodegenerative injuries and diseases such as stroke, Alzheimer's disease, Parkinson's disease, Huntington's disease and several lysosomal storage disorders diseases, including Tay Sach's disease. Mass spectrometry (MS) has become a useful means to better understand ganglioside composition and function. Imaging mass spectrometry (IMS) provides the added benefit of placing analytical information within an anatomical context. This review article will discuss recent advances in MS-based detection methods, with a focus on IMS-based approaches to help understand the spatial-specific role gangliosides in the healthy brain as in CNS injuries and disease.

Graphical abstract: Imaging mass spectrometry allows for neuroanatomic-specific detection of gangliosides in the healthy and diseased brain

Article information

Article type
Critical Review
Submitted
12 noy 2019
Accepted
05 fev 2020
First published
07 fev 2020

Analyst, 2020,145, 2473-2481

Imaging mass spectrometry allows for neuroanatomic-specific detection of gangliosides in the healthy and diseased brain

W. X. Wang and S. N. Whitehead, Analyst, 2020, 145, 2473 DOI: 10.1039/C9AN02270H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements