Issue 9, 2019

Laboratory of the future: a modular flow platform with multiple integrated PAT tools for multistep reactions

Abstract

Currently, the monitoring of multistep continuous flow processes by multiple analytical sources is still seen as a resource intensive and specialized activity. In this article, the coupling of a modular microreactor platform with real-time monitoring by inline IR and NMR, in addition to online UPLC, is described. Using this platform, we rapidly generated experimental data (17 iterations in under 2 hours) to access information on the different chemical species at multiple points within the reactor and to generate process understanding. We highlight the application of the platform in the optimization of a multistep organolithium transformation. The optimized continuous flow conditions were demonstrated in a scale-out experiment with in-process monitoring to afford the desired product in 70% isolated yield and provided a throughput of 4.2 g h−1.

Graphical abstract: Laboratory of the future: a modular flow platform with multiple integrated PAT tools for multistep reactions

Supplementary files

Article information

Article type
Paper
Submitted
24 fev 2019
Accepted
08 apr 2019
First published
08 apr 2019
This article is Open Access
Creative Commons BY-NC license

React. Chem. Eng., 2019,4, 1571-1578

Laboratory of the future: a modular flow platform with multiple integrated PAT tools for multistep reactions

P. Sagmeister, J. D. Williams, C. A. Hone and C. O. Kappe, React. Chem. Eng., 2019, 4, 1571 DOI: 10.1039/C9RE00087A

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