Issue 25, 2019

A novel method for PEGylation of chitosan nanoparticles through photopolymerization

Abstract

An ultrafast and convenient method for PEGylation of chitosan nanoparticles has been established through a photopolymerization reaction between the acrylate groups of PEG and methacrylated-chitosan nanoparticles. The nanoparticle characteristics under physiological pH conditions were optimized through altered PEG chain length, concentration and duration of UV exposure. The method developed here has potential for clinical translation of chitosan nanoparticles. It also allows for the scalable and fast synthesis of nanoparticles with colloidal stability.

Graphical abstract: A novel method for PEGylation of chitosan nanoparticles through photopolymerization

Supplementary files

Article information

Article type
Paper
Submitted
29 yan 2019
Accepted
24 apr 2019
First published
07 may 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 14011-14015

A novel method for PEGylation of chitosan nanoparticles through photopolymerization

U. Bozuyuk, I. S. Gokulu, N. O. Dogan and S. Kizilel, RSC Adv., 2019, 9, 14011 DOI: 10.1039/C9RA00780F

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