Issue 15, 2019

Ligandless nickel-catalyzed transfer hydrogenation of alkenes and alkynes using water as the hydrogen donor

Abstract

The first general route for nickel-catalyzed transfer hydrogenation reaction of alkenes and alkynes using water as the hydrogen source has been developed. The method features the use of inexpensive and air-stable nickel(II) salt as the pre-catalyst and zinc powder as a reducing agent, allowing the TH reaction to occur under mild reaction conditions with a wide substrate scope and functional group tolerance. No ligand was required for this reaction. The reaction has also been applied successfully to the reduction of nitrogen-containing heterocycles.

Graphical abstract: Ligandless nickel-catalyzed transfer hydrogenation of alkenes and alkynes using water as the hydrogen donor

Supplementary files

Article information

Article type
Research Article
Submitted
09 may 2019
Accepted
09 iyn 2019
First published
11 iyn 2019

Org. Chem. Front., 2019,6, 2619-2623

Ligandless nickel-catalyzed transfer hydrogenation of alkenes and alkynes using water as the hydrogen donor

X. Hu, G. Wang, C. Qin, X. Xie, C. Zhang, W. Xu and Y. Liu, Org. Chem. Front., 2019, 6, 2619 DOI: 10.1039/C9QO00616H

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