Issue 12, 2019

Nickel-catalyzed highly regioselective hydrocyanation of alkenes with Zn(CN)2

Abstract

The first general and regioselective nickel-catalyzed hydrocyanation of terminal alkenes with Zn(CN)2 using an air-stable and inexpensive nickel(II) salt as the precatalyst has been established. The strategy avoids the use of the volatile and hazardous reagent HCN. Aryl/heteroaryl alkenes are effectively converted to branched nitrile derivatives, while aliphatic alkenes or active alkenes are transformed to linear nitriles with good to excellent regioselectivity.

Graphical abstract: Nickel-catalyzed highly regioselective hydrocyanation of alkenes with Zn(CN)2

Supplementary files

Article information

Article type
Research Article
Submitted
19 mar 2019
Accepted
26 apr 2019
First published
01 may 2019

Org. Chem. Front., 2019,6, 2037-2042

Nickel-catalyzed highly regioselective hydrocyanation of alkenes with Zn(CN)2

G. Wang, X. Xie, W. Xu and Y. Liu, Org. Chem. Front., 2019, 6, 2037 DOI: 10.1039/C9QO00396G

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