Issue 3, 2019

A two-photon AIEgen for simultaneous dual-color imaging of atherosclerotic plaques

Abstract

High-resolution imaging of lipids within the artery is of great value to obtain fundamental knowledge about their roles in atherosclerosis, but ideal probes are still lacking. In this study, we report a smart probe, namely, IND with aggregation-induced emission property for two-photon visualization of lipids within cell lines and arteries. Taking advantage of high lipid specificity, deep tissue penetrability, and excellent two-photon imaging performance, IND is capable of high-resolution imaging of lipids in cultured cells and in situ mapping of three-dimensional lipid distributions in mouse atherosclerotic plaques without tedious histological preparations. Importantly, we find that IND exhibits distinct emissive properties in the molecular monomer and dimer states; also, we uncover its remarkable applications for single-excitation dual-color imaging of lipid/water in the tissue microenvironment to reveal the ultra-structure of atherosclerotic plaques. The findings described herein provide a simple tool with minimal disruptive procedures for studying atherosclerosis at the tissue level and a powerful strategy for the development of imaging-based diagnostic techniques with color switching capability.

Graphical abstract: A two-photon AIEgen for simultaneous dual-color imaging of atherosclerotic plaques

Supplementary files

Article information

Article type
Communication
Submitted
13 okt 2018
Accepted
22 noy 2018
First published
23 noy 2018

Mater. Horiz., 2019,6, 546-553

A two-photon AIEgen for simultaneous dual-color imaging of atherosclerotic plaques

B. Situ, M. Gao, X. He, S. Li, B. He, F. Guo, C. Kang, S. Liu, L. Yang, M. Jiang, Y. Hu, B. Z. Tang and L. Zheng, Mater. Horiz., 2019, 6, 546 DOI: 10.1039/C8MH01293H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements