Issue 13, 2019

Continuous manufacturing – the Green Chemistry promise?

Abstract

Continuous manufacturing and Green Chemistry, are two promising approaches to synthesis with underutilized potential that are gaining traction by the wider pharmaceutical community. We review Green Chemistry advances resulting when transitioning to continuous manufacturing with focus on Green Chemistry elements inherent in flow chemistry and related separation processes. Case studies of continuous manufacturing represented by the F3 (Flexible, Fast, and Future) project, cGPM manufacturing at Eli Lilly, and the MIT pharmaceuticals on demand projects provide examples of Green Chemistry advances realised. Throughout the review, Green Chemistry advances are identified in terms of the pertinent principles of Green Chemistry. A count of the occurrences of the different principles of Green Chemistry reveals that the principle of prevention greatly overshadows all other principles.

Graphical abstract: Continuous manufacturing – the Green Chemistry promise?

Article information

Article type
Critical Review
Submitted
04 mar 2019
Accepted
21 may 2019
First published
21 may 2019
This article is Open Access
Creative Commons BY license

Green Chem., 2019,21, 3481-3498

Continuous manufacturing – the Green Chemistry promise?

L. Rogers and K. F. Jensen, Green Chem., 2019, 21, 3481 DOI: 10.1039/C9GC00773C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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