Issue 40, 2019

Mechanistic insight into novel sulfoxide containing SABRE polarisation transfer catalysts

Abstract

Signal Amplification By Reversible Exchange (SABRE) is a hyperpolarisation technique that commonly uses [Ir(H)2(carbene)(substrate)3]Cl complexes to catalytically transfer magnetisation from para-hydrogen derived hydride ligands to coordinated substrates. Here, we explore the reactivity of a novel class of such catalysts based on sulfoxide containing [IrCl(H)2(carbene)(DMSO)2], which are involved in the hyperpolarisation of pyruvate using SABRE. We probe the reactivity of this species by NMR and DFT and upon reaction with sodium pyruvate establish the formation of two isomers of [Ir(H)22-pyruvate)(DMSO)(IMes)]. Studies with related disodium oxalate yield [Ir2(H)4(IMes)2(DMSO)222-Oxalate)] that is characterised by NMR and X-ray diffraction.

Graphical abstract: Mechanistic insight into novel sulfoxide containing SABRE polarisation transfer catalysts

Supplementary files

Article information

Article type
Paper
Submitted
18 iyl 2019
Accepted
06 sen 2019
First published
24 sen 2019
This article is Open Access
Creative Commons BY license

Dalton Trans., 2019,48, 15198-15206

Mechanistic insight into novel sulfoxide containing SABRE polarisation transfer catalysts

Ben. J. Tickner, J. S. Lewis, R. O. John, A. C. Whitwood and S. B. Duckett, Dalton Trans., 2019, 48, 15198 DOI: 10.1039/C9DT02951F

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