Issue 79, 2019

Total synthesis of verucopeptin, an inhibitor of hypoxia-inducible factor 1 (HIF-1)

Abstract

Verucopeptin is an inhibitor of hypoxia-inducible factor 1 (HIF-1), which is a promising target for cancer chemotherapy. Here, we report the first total synthesis of verucopeptin via condensation of the depsipeptide core and the polyketide side chain unit including three branched methyl groups after the synthesis of each segment.

Graphical abstract: Total synthesis of verucopeptin, an inhibitor of hypoxia-inducible factor 1 (HIF-1)

Supplementary files

Article information

Article type
Communication
Submitted
09 avq 2019
Accepted
06 sen 2019
First published
18 sen 2019

Chem. Commun., 2019,55, 11956-11959

Total synthesis of verucopeptin, an inhibitor of hypoxia-inducible factor 1 (HIF-1)

N. Takahashi, H. Hayashi, V. Poznaks and H. Kakeya, Chem. Commun., 2019, 55, 11956 DOI: 10.1039/C9CC06169J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements