Issue 47, 2019

Small-molecule fluorescent probes for specific detection and imaging of chemical species inside lysosomes

Abstract

In the past few years, the preparation of novel small-molecule fluorescent probes for specific detection and imaging of chemical species inside lysosomes has attracted considerable attention because of their wide applications in chemistry, biology, and medical science. This feature article summarizes the recent advances in the design and preparation of small-molecule fluorescent probes for specific detection of chemical species inside lysosomes. In addition, their properties and applications for the detection and imaging of pH, H2O2, HOCl, O2˙, lipid peroxidation, H2S, HSO3, thiols, NO, ONOO, HNO, Zn2+, Cu2+, enzymes, etc. in lysosomes are discussed as well.

Graphical abstract: Small-molecule fluorescent probes for specific detection and imaging of chemical species inside lysosomes

Article information

Article type
Feature Article
Submitted
29 apr 2019
Accepted
07 may 2019
First published
08 may 2019

Chem. Commun., 2019,55, 6629-6671

Small-molecule fluorescent probes for specific detection and imaging of chemical species inside lysosomes

J. Zhu, Z. Xu, Y. Yang and L. Xu, Chem. Commun., 2019, 55, 6629 DOI: 10.1039/C9CC03299A

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