Issue 7, 2018

Insulin hexamer dissociation dynamics revealed by photoinduced T-jumps and time-resolved X-ray solution scattering

Abstract

The structural dynamics of insulin hexamer dissociation were studied by the photoinduced temperature jump technique and monitored by time-resolved X-ray scattering. The process of hexamer dissociation was found to involve several transient intermediates, including an expanded hexamer and an unstable tetramer. Our findings provide insights into the mechanisms of protien–protein association.

Graphical abstract: Insulin hexamer dissociation dynamics revealed by photoinduced T-jumps and time-resolved X-ray solution scattering

Supplementary files

Article information

Article type
Communication
Submitted
25 yan 2018
Accepted
24 may 2018
First published
25 may 2018

Photochem. Photobiol. Sci., 2018,17, 874-882

Author version available

Insulin hexamer dissociation dynamics revealed by photoinduced T-jumps and time-resolved X-ray solution scattering

D. Rimmerman, D. Leshchev, D. J. Hsu, J. Hong, B. Abraham, I. Kosheleva, R. Henning and L. X. Chen, Photochem. Photobiol. Sci., 2018, 17, 874 DOI: 10.1039/C8PP00034D

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