Issue 10, 2018

Complex formation of nickel(ii) and zinc(ii) ions with peptide fragments of rat amylin

Abstract

Nickel(II) and zinc(II) complexes of the 19–22 peptide fragments of rat amylin were studied by potentiometric, UV-vis, CD and NMR spectroscopic methods. The results revealed that in contrast with the corresponding copper(II) complexes, the –SSNN– sequence (or 19–22 residues of rat amylin) cannot be the primary anchoring site for nickel(II) and zinc(II) ions. For nickel(II) containing systems, an increased stability of the corresponding complexes was, however, measured and explained by an equilibrium between the common (NH2,3N(peptide)) and (NH2,2N(peptide),N(asparagine)) coordination modes in a basic solution. From the comparison of the results obtained for the copper(II), nickel(II) and zinc(II) ions, it can be unambiguously stated that the rat amylin have an outstanding affinity for copper(II) binding.

Graphical abstract: Complex formation of nickel(ii) and zinc(ii) ions with peptide fragments of rat amylin

Associated articles

Supplementary files

Article information

Article type
Paper
Submitted
24 noy 2017
Accepted
06 fev 2018
First published
06 fev 2018

New J. Chem., 2018,42, 8131-8136

Complex formation of nickel(II) and zinc(II) ions with peptide fragments of rat amylin

Á. Dávid, É. T. Hartman, N. Lihi, I. Sóvágó and K. Várnagy, New J. Chem., 2018, 42, 8131 DOI: 10.1039/C7NJ04605G

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