Issue 19, 2018

Translating solid state organic synthesis from a mixer mill to a continuous twin screw extruder

Abstract

A study on the translation of a solid-state synthetic reaction from a mechanochemical mixer-mill to a continuous twin-screw extruder is discussed herein. The study highlights some considerations to be made and parameters to be tested in the context of a model fluorination reaction, which is the first organic fluorination to be attempted using extrusion. Upon optimization, which features the first use of grinding auxiliary solids to enable effective synthetic extrusion, the difluorination reaction was successfully translated to the extruder, leading to a 100-fold improvement in Space Time Yield (STY); 29 kg m−3 day−1 in a mixer mill to 3395 kg m−3 day−1 in a twin screw extruder.

Graphical abstract: Translating solid state organic synthesis from a mixer mill to a continuous twin screw extruder

Supplementary files

Article information

Article type
Communication
Submitted
01 iyl 2018
Accepted
23 avq 2018
First published
18 sen 2018
This article is Open Access
Creative Commons BY license

Green Chem., 2018,20, 4443-4447

Translating solid state organic synthesis from a mixer mill to a continuous twin screw extruder

Q. Cao, J. L. Howard, D. E. Crawford, S. L. James and D. L. Browne, Green Chem., 2018, 20, 4443 DOI: 10.1039/C8GC02036A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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