Jump to main content
Jump to site search

Issue 6, 2018
Previous Article Next Article

Citrus peel extracts attenuated obesity and modulated gut microbiota in mice with high-fat diet-induced obesity

Author affiliations

Abstract

Polymethoxyflavones (PMFs) and hydroxyl PMFs (HOPMFs) are mainly found in citrus peel and have shown anti-obesity potential in in vitro and in vivo studies. Herein, we have investigated the anti-obesity effects of two citrus peel extracts obtained via supercritical fluid extraction: PMF A, with a lower content of PMFs and HOPMFs, and PMF B, with a higher content of PMFs and HOPMFs. PMF A and PMF B were administered orally for 16 weeks to mice with high fat diet (HFD)-induced obesity. The results showed that PMF B decreased the lipid content more statistically significantly (p < 0.05) than PMF A in 3T3-L1 preadipocytes, reduced the adipocyte size, decreased the adipose tissue weight and alleviated the total body weight in the HFD mice. Both PMF A and PMF B reduced the adipocyte size in the perigonadal fat by markedly decreasing the levels of lipid droplets (LD) and perilipin 1 protein and Sterol regulatory element binding protein 1 (SREBP-1) expression. Compared to the case of the HFD group, PMF B altered the gut microbiota by increasing Prevotella and decreasing rc4-4 bacteria. The change in the composition of gut microbiota, the community of symbiotic and pathogenic microorganisms, may determine the metabolic health and be responsible for the anti-obesity mechanism. Our results indicate that the citrus peel extracts decrease lipid accumulation both in vivo and in vitro and should be considered for the management of overweight and obesity conditions.

Graphical abstract: Citrus peel extracts attenuated obesity and modulated gut microbiota in mice with high-fat diet-induced obesity

Back to tab navigation

Supplementary files

Article information


Submitted
28 dek 2017
Accepted
10 may 2018
First published
14 may 2018

Food Funct., 2018,9, 3363-3373
Article type
Paper

Citrus peel extracts attenuated obesity and modulated gut microbiota in mice with high-fat diet-induced obesity

Y. Tung, W. Chang, S. Li, J. Wu, V. Badmeav, C. Ho and M. Pan, Food Funct., 2018, 9, 3363 DOI: 10.1039/C7FO02066J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements