Issue 64, 2018

Oximinotrifluoromethylation of unactivated alkenes under ambient conditions

Abstract

An efficient protocol for oximinotrifluoromethylation of unactivated alkenes was developed via trifluoromethyl radical-induced intramolecular remote oximino migration under mild reaction conditions, providing a wide range of β-trifluoromethylated oximes. Other fluoroalkyl radicals were also applicable for this transformation. This method provided access to synthetically challenging medium-sized ring scaffolds and the 6,7,5-fused lactam skeleton.

Graphical abstract: Oximinotrifluoromethylation of unactivated alkenes under ambient conditions

Supplementary files

Article information

Article type
Communication
Submitted
28 iyn 2018
Accepted
17 iyl 2018
First published
18 iyl 2018

Chem. Commun., 2018,54, 8885-8888

Oximinotrifluoromethylation of unactivated alkenes under ambient conditions

N. Wang, J. Wang, Y. Guo, L. Li, Y. Sun, Z. Li, H. Zhang, Z. Guo, Z. Li and X. Liu, Chem. Commun., 2018, 54, 8885 DOI: 10.1039/C8CC05186K

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