Issue 54, 2018

Asymmetric total synthesis of (+)-ovafolinins A and B

Abstract

(+)-Ovafolinins A and B are two homologous lignans containing unique polycyclic skeletons. Benefiting from a highly diastereoselective alkylation of (S)-Taniguchi lactone, a double Friedel–Crafts reaction, a global debenzylation and a Cu(OAc)2-enabled benzylic oxidative cyclization, we present herein an efficient synthetic approach to (+)-ovafolinins A and B.

Graphical abstract: Asymmetric total synthesis of (+)-ovafolinins A and B

Supplementary files

Article information

Article type
Communication
Submitted
28 apr 2018
Accepted
14 iyn 2018
First published
16 iyn 2018

Chem. Commun., 2018,54, 7539-7541

Asymmetric total synthesis of (+)-ovafolinins A and B

X. Fang, L. Shen and X. Hu, Chem. Commun., 2018, 54, 7539 DOI: 10.1039/C8CC03456G

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