Issue 4, 2018

Palladium-catalyzed carbene/alkyne metathesis with enynones as carbene precursors: synthesis of fused polyheterocycles

Abstract

An unprecedented palladium-catalyzed novel carbene/alkyne metathesis cascade reaction of alkyne-tethered enynones is described. This reaction affords fused polyheterocycles in moderate to good yields. The transformation begins with Pd-catalyzed 5-exo-dig cyclization of the enynone to form the donor/donor metal carbene, which then undergoes metathesis with the alkyne followed by electrophilic aromatic substitution.

Graphical abstract: Palladium-catalyzed carbene/alkyne metathesis with enynones as carbene precursors: synthesis of fused polyheterocycles

Supplementary files

Article information

Article type
Communication
Submitted
25 okt 2017
Accepted
04 dek 2017
First published
04 dek 2017

Chem. Commun., 2018,54, 350-353

Palladium-catalyzed carbene/alkyne metathesis with enynones as carbene precursors: synthesis of fused polyheterocycles

Y. Zheng, M. Bao, R. Yao, L. Qiu and X. Xu, Chem. Commun., 2018, 54, 350 DOI: 10.1039/C7CC08221E

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