Issue 40, 2017

Development of contact-killing non-leaching antimicrobial guanidyl-functionalized polymers via click chemistry

Abstract

An expedient and efficient method applied to synthesize click-suitable penta-substituted guanidines at room temperature is hereby described. The guanidine containing polyurethanes (PU-TMGs) were prepared via click reaction (copper catalyzed alkyne-azide [3 + 2] cycloaddition, CuAAC), which was performed either before or after polymerization to incorporate the guanidine. The guanidine-functionalized polymers exhibited strong contact-killing antibacterial activity against both Gram-negative and Gram-positive bacteria. There is around 99.9% killing of S. aureus and 98.0% killing of E. coli when TMG weight percentage content in PU-TMG is around 1%. Covalent conjugation of the guanidine groups to the polymers prevents leaching. The conjugation also reduces cytotoxicity of the materials and preserves long-term antimicrobial activity.

Graphical abstract: Development of contact-killing non-leaching antimicrobial guanidyl-functionalized polymers via click chemistry

Article information

Article type
Paper
Submitted
06 mar 2017
Accepted
02 may 2017
First published
10 may 2017
This article is Open Access
Creative Commons BY license

RSC Adv., 2017,7, 24903-24913

Development of contact-killing non-leaching antimicrobial guanidyl-functionalized polymers via click chemistry

K. Peng, T. Zou, W. Ding, R. Wang, J. Guo, J. J. Round, W. Tu, C. Liu and J. Hu, RSC Adv., 2017, 7, 24903 DOI: 10.1039/C7RA02706K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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