Issue 9, 2017

Supramolecular conjugated polymer materials for organelle imaging in living cells

Abstract

A novel supramolecular system based on conjugated polymers was developed to realize specific targeting and imaging of organelles in living cells. The carboxyl group-modified polythiophene derivative (PT) forms a complex with six histidine equipped Tat peptide via Ni2+ ion chelation, hydrogen bonds and electrostatic interactions (PT/Ni2+/Tat-His6). The complex can reassemble with RFP-His10 due to the relatively high affinity of Ni2+ towards His10-tag compared to His6-tag. Thus, the PT/Ni2+/Tat-His6 complex could selectively label and image organelles expressing His10-tag in living cells with high stability.

Graphical abstract: Supramolecular conjugated polymer materials for organelle imaging in living cells

Supplementary files

Article information

Article type
Research Article
Submitted
17 mar 2017
Accepted
14 apr 2017
First published
17 apr 2017

Mater. Chem. Front., 2017,1, 1768-1772

Supramolecular conjugated polymer materials for organelle imaging in living cells

R. Hu, S. Li, H. Lu, L. Liu, F. Lv and S. Wang, Mater. Chem. Front., 2017, 1, 1768 DOI: 10.1039/C7QM00105C

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