Issue 10, 2015

Dihydrofolate reductase inhibitory peptides screened from a structured designed β-loop peptide library displayed on phage

Abstract

Enzyme inhibitory peptides with a loop structure stabilized using an antiparallel β-sheet scaffold (β-loop peptide) were obtained from a designed peptide phage library. Human dihydrofolate reductase (hDHFR) was used as the target enzyme. The obtained β-loop peptides were competitive inhibitors of hDHFR with micromolar inhibition constants and dissociation constants.

Graphical abstract: Dihydrofolate reductase inhibitory peptides screened from a structured designed β-loop peptide library displayed on phage

Supplementary files

Article information

Article type
Communication
Submitted
06 may 2015
Accepted
17 iyn 2015
First published
29 iyn 2015

Mol. BioSyst., 2015,11, 2713-2716

Author version available

Dihydrofolate reductase inhibitory peptides screened from a structured designed β-loop peptide library displayed on phage

H. Tsutsumi, K. Nakano and H. Mihara, Mol. BioSyst., 2015, 11, 2713 DOI: 10.1039/C5MB00316D

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