Issue 4, 2015

One-pot highly diastereoselective annulation to N-unprotected tetrasubstituted 2-pyrrolines

Abstract

A one-pot DABCO-catalysed Michael addition of glycine imine-derived esters to trans-2-aroyl-3-arylacrylonitriles followed by a deprotection/cyclization/tautomerization sequence afforded tetrasubstituted N-unprotected trans-2-pyrrolines in up to 96% yield.

Graphical abstract: One-pot highly diastereoselective annulation to N-unprotected tetrasubstituted 2-pyrrolines

Supplementary files

Article information

Article type
Communication
Submitted
10 noy 2014
Accepted
05 yan 2015
First published
06 yan 2015

Green Chem., 2015,17, 2137-2140

One-pot highly diastereoselective annulation to N-unprotected tetrasubstituted 2-pyrrolines

S. Meninno, A. Capobianco, A. Peluso and A. Lattanzi, Green Chem., 2015, 17, 2137 DOI: 10.1039/C4GC02191F

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