Issue 1, 2015

Pyridynes and indolynes as building blocks for functionalized heterocycles and natural products

Abstract

Heterocyclic arynes, or hetarynes, have been studied for over 100 years. However, challenges associated with observing these reactive species, as well as developing synthetically useful methods for their generation and trapping, have limited their use. This review provides a brief historical perspective on the field of hetarynes, in addition to a discussion of pyridyne and indolyne methodologies. Moreover, this review highlights the use of pyridynes, indolynes, and related strained intermediates in natural product synthesis.

Graphical abstract: Pyridynes and indolynes as building blocks for functionalized heterocycles and natural products

Article information

Article type
Feature Article
Submitted
16 avq 2014
Accepted
04 sen 2014
First published
05 sen 2014

Chem. Commun., 2015,51, 34-45

Pyridynes and indolynes as building blocks for functionalized heterocycles and natural products

A. E. Goetz, T. K. Shah and N. K. Garg, Chem. Commun., 2015, 51, 34 DOI: 10.1039/C4CC06445C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements