Issue 24, 2015

Cu2+-mediated fluorescence switching of gold nanoclusters for the selective detection of clioquinol

Abstract

It is of great significance to sense clioquinol (CQ) in a simple and fast way because of its potential application in the treatment of neurodegenerative diseases. In this contribution, we proposed a Cu2+-mediated fluorescence switchable strategy to detect CQ by taking bovine serum albumin (BSA) protected gold nanoclusters (AuNCs) as probes. It was found that the strong red fluorescence of BSA-protected AuNCs at 610 nm could be effectively quenched by Cu2+ (off state) and reversibly recovered by CQ (on state) owing to the specific coordination of CQ and Cu2+. Under the optimal conditions, there was a good linear relationship between the off–on efficiency (Eoff–on) and the amount of CQ in the range of 1–12 μM (R2 = 0.9902), with a detection limit of 0.63 μM (3σ). The “turn off–on” mode and the fast and unique complexation of CQ and Cu2+ endow AuNCs with high specificity for CQ sensing. The proposed strategy is label-free, fast and selective, which is applicable to the analysis of CQ in cream with satisfactory results.

Graphical abstract: Cu2+-mediated fluorescence switching of gold nanoclusters for the selective detection of clioquinol

Supplementary files

Article information

Article type
Paper
Submitted
24 sen 2015
Accepted
30 okt 2015
First published
30 okt 2015

Analyst, 2015,140, 8194-8200

Author version available

Cu2+-mediated fluorescence switching of gold nanoclusters for the selective detection of clioquinol

J. Wang, Y. Chang, P. Zhang, S. Q. Lie, P. F. Gao and C. Z. Huang, Analyst, 2015, 140, 8194 DOI: 10.1039/C5AN01975C

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