Issue 7, 2014

Copper-mediated difluoromethylation of electron-poor aryl iodides at room temperature

Abstract

A convenient copper-mediated direct difluoromethylation of electron-deficient aryl iodides, as well as heteroaryl and β-styryl iodides, using TMSCF2H has been developed. This one-step protocol proceeded at room temperature, affording various difluoromethylated products in moderate to excellent yields.

Graphical abstract: Copper-mediated difluoromethylation of electron-poor aryl iodides at room temperature

Supplementary files

Article information

Article type
Research Article
Submitted
22 may 2014
Accepted
18 iyn 2014
First published
20 iyn 2014

Org. Chem. Front., 2014,1, 774-776

Copper-mediated difluoromethylation of electron-poor aryl iodides at room temperature

X. Jiang, Z. Chen, X. Xu and F. Qing, Org. Chem. Front., 2014, 1, 774 DOI: 10.1039/C4QO00153B

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