Issue 3, 2014

Palladium-catalyzed cascade cyclization for the construction of spiro-N,O-acetals

Abstract

A facile Pd-catalyzed cascade cyclization of N-alkenylamine and pyruvic acids has been developed to construct spiro-N,O-acetals. This transformation was initiated by an intramolecular oxidative amination of alkenes, followed by hydrolysis to give a ketone intermediate, which further reacts with pyruvic acid to deliver the final spiro-N,O-acetals.

Graphical abstract: Palladium-catalyzed cascade cyclization for the construction of spiro-N,O-acetals

Supplementary files

Article information

Article type
Research Article
Submitted
02 yan 2014
Accepted
29 yan 2014
First published
06 mar 2014

Org. Chem. Front., 2014,1, 289-293

Palladium-catalyzed cascade cyclization for the construction of spiro-N,O-acetals

J. Cheng, P. Chen and G. Liu, Org. Chem. Front., 2014, 1, 289 DOI: 10.1039/C4QO00002A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements