Issue 2, 2014

Asymmetric hydrogenation of α-arylacrylic and β-arylbut-3-enoic acids catalyzed by a Rh(i) complex of a monodentate secondary phosphine oxide ligand

Abstract

The RhI complexes of chiral secondary phosphine oxide ligands have been disclosed to be efficient for the catalytic asymmetric hydrogenation of α-arylacrylic and β-arylbut-3-enoic acids, providing the corresponding chiral α-arylpropanoic and β-arylbutanoic acids in excellent yields with up to 97% ee, including several anti-inflammatory drugs.

Graphical abstract: Asymmetric hydrogenation of α-arylacrylic and β-arylbut-3-enoic acids catalyzed by a Rh(i) complex of a monodentate secondary phosphine oxide ligand

Supplementary files

Article information

Article type
Research Article
Submitted
18 noy 2013
Accepted
12 yan 2014
First published
24 yan 2014

Org. Chem. Front., 2014,1, 155-160

Asymmetric hydrogenation of α-arylacrylic and β-arylbut-3-enoic acids catalyzed by a Rh(I) complex of a monodentate secondary phosphine oxide ligand

K. Dong, Y. Li, Z. Wang and K. Ding, Org. Chem. Front., 2014, 1, 155 DOI: 10.1039/C3QO00042G

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