Issue 30, 2012

A unified access to diverse heteroaromatic scaffolds using the radical chemistry of xanthates

Abstract

The degenerate transfer of xanthates allows generally difficult radical transformations, such as intermolecular additions to unactivated alkenes and cyclisations onto aromatic and heteroaromatic rings, to be accomplished under very practical experimental conditions. This translates into numerous approaches for the construction or modification of heteroaromatic structures. The present report aims to provide a brief overview of the various synthetic possibilities, with particular emphasis on medicinally interesting families of compounds.

Graphical abstract: A unified access to diverse heteroaromatic scaffolds using the radical chemistry of xanthates

Article information

Article type
Perspective
Submitted
21 yan 2012
Accepted
21 fev 2012
First published
22 fev 2012

Org. Biomol. Chem., 2012,10, 5707-5719

A unified access to diverse heteroaromatic scaffolds using the radical chemistry of xanthates

M. El Qacemi, L. Petit, B. Quiclet-Sire and S. Z. Zard, Org. Biomol. Chem., 2012, 10, 5707 DOI: 10.1039/C2OB25169H

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