Issue 71, 2012

Imaging beyond the proteome

Abstract

Imaging technologies developed in the early 20th century achieved contrast solely by relying on macroscopic and morphological differences between the tissues of interest and the surrounding tissues. Since then, there has been a movement toward imaging at the cellular and molecular level in order to visualize biological processes. This rapidly growing field is known as molecular imaging. In the last decade, many methodologies for imaging proteins have emerged. However, most of these approaches cannot be extended to imaging beyond the proteome. Here, we highlight some of the recently developed technologies that enable imaging of non-proteinaceous molecules in the cell: lipids, signalling molecules, inorganic ions, glycans, nucleic acids, small-molecule metabolites, and protein post-translational modifications such as phosphorylation and methylation.

Graphical abstract: Imaging beyond the proteome

Article information

Article type
Feature Article
Submitted
13 mar 2012
Accepted
14 iyn 2012
First published
17 iyl 2012

Chem. Commun., 2012,48, 8864-8879

Imaging beyond the proteome

P. V. Chang and C. R. Bertozzi, Chem. Commun., 2012, 48, 8864 DOI: 10.1039/C2CC31845H

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