Issue 21, 2024

Synthesis of highly luminescent core–shell nanoprobes in a single pot for ofloxacin detection in blood serum and water

Abstract

Antibiotics are commonly used as antibacterial medications due to their extensive and potent therapeutic properties. However, the overconsumption of these chemicals leads to their accumulation in the human body via the food chain, amplifying drug resistance and compromising immunity, thus presenting a significant hazard to human health. Antibiotics are classified as organic pollutants. Therefore, it is crucial to conduct research on precise methodologies for detecting antibiotics in many substances, including food, pharmaceutical waste, and biological samples like serum and urine. The methodology described in this research paper introduces an innovative technique for producing nanoparticles using silica as the shell material, iron oxide as the core material, and carbon as the shell dopant. By integrating a carbon-doped silica shell, this substance acquires exceptional fluorescence characteristics and a substantial quantum yield value of 80%. By capitalising on this characteristic of the substance, we have effectively constructed a fluorescent sensor that enables accurate ofloxacin analysis, with a detection limit of 1.3 × 10−6 M and a linear range of concentrations from 0 to 120 × 10−6 M. We also evaluated the potential of CSIONPs for OLF detection in blood serum and tap water analysis. The obtained relative standard deviation values were below 3.5%. The percentage of ofloxacin recovery from blood serum ranged from 95.52% to 103.28%, and from 89.9% to 96.0% from tap water.

Graphical abstract: Synthesis of highly luminescent core–shell nanoprobes in a single pot for ofloxacin detection in blood serum and water

Supplementary files

Article information

Article type
Paper
Submitted
21 dek 2023
Accepted
04 mar 2024
First published
15 may 2024

Dalton Trans., 2024,53, 8958-8968

Synthesis of highly luminescent core–shell nanoprobes in a single pot for ofloxacin detection in blood serum and water

P. Kadian, A. Singh, M. Kumar, K. Kumari, D. Sharma and J. K. Randhawa, Dalton Trans., 2024, 53, 8958 DOI: 10.1039/D3DT04295B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements