Issue 48, 2023

Zinc-based biomaterials for bone repair and regeneration: mechanism and applications

Abstract

Zinc (Zn) is one of the most important trace elements in the human body and plays a key role in various physiological processes, especially in bone metabolism. Zn-containing materials have been reported to enhance bone repair through promoting cell proliferation, osteogenic activity, angiogenesis, and inhibiting osteoclast differentiation. Therefore, Zn-based biomaterials are potential substitutes for traditional bone grafts. In this review, the specific mechanisms of bone formation promotion by Zn-based biomaterials were discussed, and recent developments in their application in bone tissue engineering were summarized. Moreover, the challenges and perspectives of Zn-based biomaterials were concluded, revealing their attractive potential and development directions in the future.

Graphical abstract: Zinc-based biomaterials for bone repair and regeneration: mechanism and applications

Article information

Article type
Review Article
Submitted
17 avq 2023
Accepted
11 noy 2023
First published
13 noy 2023

J. Mater. Chem. B, 2023,11, 11405-11425

Zinc-based biomaterials for bone repair and regeneration: mechanism and applications

X. Wen, J. Wang, X. Pei and X. Zhang, J. Mater. Chem. B, 2023, 11, 11405 DOI: 10.1039/D3TB01874A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements