Issue 13, 2023

Recent advances in intramolecular kinetic resolution reactions

Abstract

Kinetic resolution is a practical method that affords recovered starting materials and products in high enantiomeric excess from relatively simple racemic starting materials. However, intramolecular kinetic resolution is less reported due to its high reliance on designed substrates and catalysts that must match perfectly compared to intermolecular pathways. In this review, achievements in intramolecular kinetic resolution have been summarized and systematically discussed. The current review is divided into five sections based on different reaction types, mainly including cyclization, elimination, isomerization, rearrangement and miscellaneous reactions. The aim of this review article is to highlight the importance and elegance of this specialized resolution pathway in the construction of important and attractive chiral skeletons.

Graphical abstract: Recent advances in intramolecular kinetic resolution reactions

Article information

Article type
Review Article
Submitted
14 apr 2023
Accepted
31 may 2023
First published
02 iyn 2023

Org. Chem. Front., 2023,10, 3401-3428

Recent advances in intramolecular kinetic resolution reactions

T. Peng, S. Li, D. Yang and L. Wang, Org. Chem. Front., 2023, 10, 3401 DOI: 10.1039/D3QO00563A

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