Issue 37, 2020

Delivery of amino acid oxidase via catalytic nanocapsules to enable effective tumor inhibition

Abstract

Amino acids are the fundamental building blocks of proteins in tumor cells. The consumption of amino acid can be an effective approach for destroying the tumor cytoskeleton and malfunctioning of the intracellular metabolic balance. Following this concept, herein, amino acid oxidase (AAO) is delivered by hollow Fe3+/tannic acid nanocapsules (HFe–TA) and incorporated within the cancer cell membrane (M) for the first time for synergistic tumor therapy. In this system (M@AAO@HFe–TA), the intracellularly delivered AAO molecules catalyze the oxidative deamination effectively and consume amino acids significantly. The upregulation of intracellular acid and H2O2 concentration facilitates the HFe–TA mediated Fenton reaction and enhances the induction of cytotoxic ˙OH. With the combined effects, considerable in vitro and in vivo tumor inhibition was achieved by M@AAO@Fe–TA due to the activated Bcl-2/Bax/Cyt C/caspase 3 mitochondrial apoptotic pathway. This study offers an alternative therapeutic platform, functioning as a biomimetic cascade nanozyme, to enable synergistic starvation and chemodynamic tumor therapy with high efficacy.

Graphical abstract: Delivery of amino acid oxidase via catalytic nanocapsules to enable effective tumor inhibition

Supplementary files

Article information

Article type
Paper
Submitted
05 iyn 2020
Accepted
08 avq 2020
First published
10 avq 2020

J. Mater. Chem. B, 2020,8, 8546-8557

Delivery of amino acid oxidase via catalytic nanocapsules to enable effective tumor inhibition

Q. Chu, H. Zhu, B. Liu, G. Cao, C. Fang, Y. Wu, X. Li and G. Han, J. Mater. Chem. B, 2020, 8, 8546 DOI: 10.1039/D0TB01425G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements