Issue 43, 2020

Time-dependent covalent network formation in extrudable hydrogels

Abstract

The fabrication of hydrogel materials has gained increased attention for a broad range of biomedical and biotechnological applications. However, one longstanding challenge in the field is to develop hydrogels that can be easily processed into the desired form factor, while achieving the necessary final physical and biochemical properties. Herein, we report a shear-thinning hydrogel ink that can be photo-cured to create a stretchable, suturable hydrogel whose polymer network is formed via the combination of thiol-Michael addition and radical polymerization. A shear-thinning hydrogel based on bis-methacrylated Pluronic® F-127 was modified with varying equivalents of 2,2′-(ethylenedioxy)diethanethiol (EDT) as an additive. We observed that aging the hydrogel over time prior to extrusion allowed the relatively slow thiol-Michael addition to occur (between thiol and methacrylate) prior to UV initiated photopolymerization of the methacrylates. The viscoelastic properties of these hydrogels could be tuned based on the amount of EDT added, and the aging time of the hydrogel formulation. The changes to the physical properties of the hydrogels were attributed to the increased chain length between network junctions that resulted from the thiol-Michael addition reactions. The optimized hydrogel composition was then extruded from a coaxial nozzle to produce hydrogel tubes that, after curing, were resistant to tearing and were suturable. These extrudable synthetic hydrogels with tunable viscoelastic properties are promising for tissue engineering applications and as surgical training models for human vasculature.

Graphical abstract: Time-dependent covalent network formation in extrudable hydrogels

Supplementary files

Article information

Article type
Paper
Submitted
08 avq 2020
Accepted
07 sen 2020
First published
17 sen 2020

Polym. Chem., 2020,11, 6910-6918

Author version available

Time-dependent covalent network formation in extrudable hydrogels

D. Karis and A. Nelson, Polym. Chem., 2020, 11, 6910 DOI: 10.1039/D0PY01129K

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