Issue 13, 2020

E-factor analysis of a pilot plant for end-to-end integrated continuous manufacturing (ICM) of pharmaceuticals

Abstract

Most drugs are still manufactured by time-intensive and cost-inefficient batch processes; however, the pharmaceutical industry is undergoing a transition to continuous processes to benefit from the reduced lead time, cost, and footprint and improved quality associated with this new methodology. Herein we report some key results of a fully automated end-to-end integrated continuous manufacturing (ICM) pilot plant, and describe the relevant E-factor analysis. The overall yields of the batch and ICM processes are 86.4%, and 88.0%, respectively. The solvent recovery yields for Solvents 1 and 2 are 95.8%, and 94.1% in batch, and are 98.3% and 94.9% in the ICM process. The E-factor value reduced significantly from 1.627 with batch to 0.770 with ICM (∼53% reduction), and after integrating the Solvent Recovery unit operation it decreased from 0.292 for the batch process to 0.210 for ICM (∼30% reduction). The application of a seamless, continuous ICM process could reduce waste generation and lower the E-factor, resulting in a positive outcome for our planet.

Graphical abstract: E-factor analysis of a pilot plant for end-to-end integrated continuous manufacturing (ICM) of pharmaceuticals

Article information

Article type
Paper
Submitted
21 apr 2020
Accepted
11 iyn 2020
First published
11 iyn 2020

Green Chem., 2020,22, 4350-4356

E-factor analysis of a pilot plant for end-to-end integrated continuous manufacturing (ICM) of pharmaceuticals

C. Hu, C. J. Testa, S. C. Born, W. Wu, K. Shvedova, R. Sayin, B. S. Halkude, F. Casati, A. Ramnath, P. Hermant, B. Takizawa, T. F. O'Connor, X. Yang, S. Ramanujam and S. Mascia, Green Chem., 2020, 22, 4350 DOI: 10.1039/D0GC01397H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements