Issue 24, 2020

An alpha/beta chimeric peptide molecular brush for eradicating MRSA biofilms and persister cells to mitigate antimicrobial resistance

Abstract

Infections involving methicillin-resistant Staphylococcus aureus present great challenges, especially when biofilms and persister cells are involved. In this work, an α/β chimeric polypeptide molecular brush (α/β CPMB) is reported to show excellent performance in inhibiting the formation of biofilms and eradicating established biofilms. Additionally, the polymer brush efficiently killed metabolically inactive persister cells that are antibiotic-insensitive. Antimicrobial mechanism studies showed that α/β CPMB causes membrane disturbance and a substantial increase in reactive oxygen species (ROS) levels to kill bacteria, and mesosome-like structure formation was also observed. Furthermore, the polymer brush was able to kill clinically isolated multidrug resistant Gram-positive bacteria with no risk of antimicrobial resistance. The α/β CPMB has demonstrated great potential in addressing the great challenge of eradicating multidrug resistant Gram-positive bacterial infections.

Graphical abstract: An alpha/beta chimeric peptide molecular brush for eradicating MRSA biofilms and persister cells to mitigate antimicrobial resistance

Supplementary files

Article information

Article type
Paper
Submitted
20 iyl 2020
Accepted
02 sen 2020
First published
14 sen 2020

Biomater. Sci., 2020,8, 6883-6889

An alpha/beta chimeric peptide molecular brush for eradicating MRSA biofilms and persister cells to mitigate antimicrobial resistance

X. Xiao, S. Zhang, S. Chen, Y. Qian, J. Xie, Z. Cong, D. Zhang, J. Zou, W. Zhang, Z. Ji, R. Cui, Z. Qiao, W. Jiang, Y. Dai, Y. Wang, X. Shao, Y. Sun, J. Xia, J. Fei and R. Liu, Biomater. Sci., 2020, 8, 6883 DOI: 10.1039/D0BM01211D

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