Issue 73, 2019

Photoinduced synthesis of fluorinated dibenz[b,e]azepines via radical triggered cyclization

Abstract

A simple, mild and efficient approach to access fluorinated dibenz[b,e]azepines via visible-light photoredox catalysis is presented. Inexpensive and commercially available fluoroalkyl anhydrides in concert with pyridine N-oxide are employed as the source of the fluoroalkyl radicals. A one-pot process involving the trifluoroacetylation of unprotected secondary benzyl amines followed by radical cyclization could also afford the desired fluorinated dibenz[b,e]azepines.

Graphical abstract: Photoinduced synthesis of fluorinated dibenz[b,e]azepines via radical triggered cyclization

Supplementary files

Article information

Article type
Communication
Submitted
28 iyn 2019
Accepted
12 avq 2019
First published
12 avq 2019

Chem. Commun., 2019,55, 10848-10851

Photoinduced synthesis of fluorinated dibenz[b,e]azepines via radical triggered cyclization

X. Qi, H. Zhang, Z. Pan, R. Liang, C. Zhu, J. Li, Q. Tong, X. Gao, L. Wu and J. Zhong, Chem. Commun., 2019, 55, 10848 DOI: 10.1039/C9CC04977K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements