Issue 28, 2018

Hierarchical nanocomposites of graphene oxide and PEGylated protoporphyrin as carriers to load doxorubicin hydrochloride for trimodal synergistic therapy

Abstract

Multimodal and synergistic therapy of cancer has appeared as one of the most promising strategies in treating cancer. Here, we report a supramolecular hierarchical nanocomposite for combination photodynamic, photothermal, and chemotherapy. Graphene oxide (GO, photothermal agent for photothermal therapy, PTT), protoporphyrin IX (PpIX, photosensitizer for photodynamic therapy, PDT), and hydrophilic anticancer drug doxorubicin hydrochloride (DOX·HCl, therapeutic for chemotherapy) are involved in hierarchical self-assembled nanocomposites via supramolecular interactions. PEGylated PpIX (PEG–PpIX) is prepared to improve the stability of GO in physiological conditions. The nanocomposite GO(PEG–PpIX) is non-cytotoxic in the dark and phototoxic with light irradiation to exhibit efficient PTT and PDT effects. The drug loading content of the nanocomposite DOX/GO(PEG–PpIX) is as high as 15.9% and the drug release shows a pH-dependent profile. The combined PDT, PTT, and chemotherapy shows an excellent in vivo antitumor effect and side effect reduction. This work presents a facile yet robust strategy to fabricate a nanocomposite for multimodal synergistic therapy.

Graphical abstract: Hierarchical nanocomposites of graphene oxide and PEGylated protoporphyrin as carriers to load doxorubicin hydrochloride for trimodal synergistic therapy

Supplementary files

Article information

Article type
Paper
Submitted
17 mar 2018
Accepted
11 iyn 2018
First published
13 iyn 2018

J. Mater. Chem. B, 2018,6, 4687-4696

Hierarchical nanocomposites of graphene oxide and PEGylated protoporphyrin as carriers to load doxorubicin hydrochloride for trimodal synergistic therapy

T. Su, F. Cheng, J. Yan, J. Cao, K. Luo, Y. Pu and B. He, J. Mater. Chem. B, 2018, 6, 4687 DOI: 10.1039/C8TB00733K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements