Smart gold nanoparticle-stabilized ultrasound microbubbles as cancer theranostics

Young Il Yoon; Xin Pang; Sungwook Jung; Guofeng Zhang; Minsuk Kong; Gang Liu; Xiaoyuan Chen

doi:10.1039/C8TB00368H

Smart gold nanoparticle-stabilized ultrasound microbubbles as cancer theranostics†

Young Il Yoon,‡^ab Xin Pang,‡^c Sungwook Jung,‡^a Guofeng Zhang,^d Minsuk Kong,^e Gang Liu

*^c and Xiaoyuan Chen

*^a

Author affiliations

* Corresponding authors

^a Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, Maryland, USA
E-mail: shawn.chen@nih.gov

^b IT and Medical Research Team, Korea Textile Development Institute (KTDI), 136 Gukchaebosangro, Seo-gu, Daegu, South Korea

^c State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China
E-mail: gangliu.cmitm@xmu.edu.cn

^d Trans-NIH Shared Resource on Biomedical Engineering and Physical Science, National Institutes of Health (NIH), Bethesda, Maryland, USA

^e Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

Abstract

Smart gold nanoparticle-stabilized microbubbles (SAuMBs) composed of a gas-filled core and shell including smart gold nanoparticles (SAuNPs) which can be aggregated in tumors were applied as ultrasound-mediated cancer theranostics. The gas core in the microstructure enabled the detection of tumors using ultrasound and facilitated the delivery of SAuNPs by sonoporation. The SAuNPs spontaneously aggregated in tumors, which allowed photoacoustic (PA) monitoring and photothermal treatment (PTT) of tumors.

This article is part of the themed collection: International Year of the Periodic Table: Precious metals for cancer treatment

Supplementary files

Article information

DOI: https://doi.org/10.1039/C8TB00368H
Article type: Communication
Submitted: 06 fev 2018
Accepted: 01 may 2018
First published: 01 may 2018

Download Citation

J. Mater. Chem. B, 2018,6, 3235-3239

Permissions

Request permissions

Smart gold nanoparticle-stabilized ultrasound microbubbles as cancer theranostics

Y. I. Yoon, X. Pang, S. Jung, G. Zhang, M. Kong, G. Liu and X. Chen, J. Mater. Chem. B, 2018, 6, 3235 DOI: 10.1039/C8TB00368H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Journal of Materials Chemistry B

Smart gold nanoparticle-stabilized ultrasound microbubbles as cancer theranostics†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Smart gold nanoparticle-stabilized ultrasound microbubbles as cancer theranostics

Social activity

Search articles by author

Spotlight

Advertisements