Issue 13, 2018

Noninvasive magnetic resonance/photoacoustic imaging for photothermal therapy response monitoring

Abstract

In vivo assessment of vascular permeability and therapeutic response provides novel insights into photothermal therapy (PTT) that is currently under clinical investigation. We have developed noninvasive imaging strategies to improve the monitoring of nanoparticle-mediated PTT responses for personalized nanomedicine. Briefly, dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and photoacoustic imaging (PAI) were applied to study the enhanced permeability and retention (EPR) effect in tumor models of different microvascular permeabilities (i.e., 4T1 mouse breast tumor model and HUH-7 human hepatoma model in nude mice). Magnetic resonance temperature imaging (MRTI) and diffusion-weighted MRI (DWI) showed that the 4T1 tumor model exhibits a higher PTT temperature response than that of the HUH-7 tumor model. Our findings demonstrate that the combined use of MRI and PAI techniques is useful in monitoring the vascular permeability and temperature status following PTT, promising to help guide PTT in future translational investigation.

Graphical abstract: Noninvasive magnetic resonance/photoacoustic imaging for photothermal therapy response monitoring

Supplementary files

Article information

Article type
Communication
Submitted
03 yan 2018
Accepted
20 fev 2018
First published
01 mar 2018

Nanoscale, 2018,10, 5864-5868

Noninvasive magnetic resonance/photoacoustic imaging for photothermal therapy response monitoring

J. Ye, G. Fu, X. Yan, J. Liu, X. Wang, L. Cheng, F. Zhang, P. Z. Sun and G. Liu, Nanoscale, 2018, 10, 5864 DOI: 10.1039/C8NR00044A

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