Issue 100, 2018

Metal free direct C(sp2)–H arylaminations using nitrosoarenes to 2-hydroxy-di(het)aryl amines as multifunctional Aβ-aggregation modulators

Abstract

An unprecedented metal free arylamination reaction involving nitrosoarenes as the electrophilic aminating agents is reported. The direct arylamination of a broad range of substrates, such as naphthols, hydroxyquinolines, hydroxyquinones, coumarins and 1,3-cyclohexadienones was achieved under operationally simple and mild conditions without the aid of additional reagents/steps for N–O bond reduction. Interestingly, novel 2-hydroxydiaryl amines were found to act as Aβ-aggregation inhibitors.

Graphical abstract: Metal free direct C(sp2)–H arylaminations using nitrosoarenes to 2-hydroxy-di(het)aryl amines as multifunctional Aβ-aggregation modulators

Supplementary files

Article information

Article type
Communication
Submitted
23 okt 2018
Accepted
23 noy 2018
First published
23 noy 2018

Chem. Commun., 2018,54, 14081-14084

Metal free direct C(sp2)–H arylaminations using nitrosoarenes to 2-hydroxy-di(het)aryl amines as multifunctional Aβ-aggregation modulators

S. K. Roy, A. Tiwari, M. Saleem and C. K. Jana, Chem. Commun., 2018, 54, 14081 DOI: 10.1039/C8CC08470J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements