Issue 29, 2017

Pd-Catalyzed regioselective C–H halogenation of quinazolinones and benzoxazinones

Abstract

A Pd-catalyzed ortho-selective halogenation of benzoxazinone and quinazolinone scaffolds has been described employing N-halosuccinimide as both a halogen source and an oxidant reagent via C–H bond activation. This transformation shows high chemo- and regioselectivities and demonstrates a broad range of benzoxazinone and quinazolinone substrates with different functional groups and has been scaled up to the gram level.

Graphical abstract: Pd-Catalyzed regioselective C–H halogenation of quinazolinones and benzoxazinones

Supplementary files

Article information

Article type
Paper
Submitted
23 iyn 2017
Accepted
05 iyl 2017
First published
05 iyl 2017

Org. Biomol. Chem., 2017,15, 6264-6268

Pd-Catalyzed regioselective C–H halogenation of quinazolinones and benzoxazinones

M. Dabiri, N. Farajinia Lehi, S. Kazemi Movahed and H. R. Khavasi, Org. Biomol. Chem., 2017, 15, 6264 DOI: 10.1039/C7OB01534H

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