Issue 2, 2015

A Zn azelate MOF: combining antibacterial effect

Abstract

A novel biocompatible and bioactive Metal–Organic Framework (BioMOF), named BioMIL-5 (Bioactive Materials from Institut Lavoisier), was hydrothermally synthesized from a Zn2+ salt and azelaic acid, both with interesting antibacterial and dermatological properties. Its structure was determined by high resolution X-ray powder diffraction, and further characterized by infrared spectroscopy, thermogravimetric analysis and elemental analysis. The determination of the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) values of BioMIL-5 in Staphylococcus aureus and Staphylococcus epidermidis demonstrated that the antimicrobial activity of the individual components of BioMIL-5 were maintained after its synthesis. Moreover, BioMIL-5 was found to be stable in water and in bacterial culture medium, especially in water, leading to the subsequent progressive release of its active constituents, AzA and Zn2+ ions. Interestingly, this slow active delivery allowed control of the growth of a S. epidermidis suspension over 7 days. The high stability of this material and the maintenance of its antibacterial properties make BioMIL-5 a good candidate for future bioapplications, for skin care and in cosmetics.

Graphical abstract: A Zn azelate MOF: combining antibacterial effect

Supplementary files

Article information

Article type
Paper
Submitted
26 apr 2014
Accepted
13 iyn 2014
First published
13 iyn 2014

CrystEngComm, 2015,17, 456-462

Author version available

A Zn azelate MOF: combining antibacterial effect

C. Tamames-Tabar, E. Imbuluzqueta, N. Guillou, C. Serre, S. R. Miller, E. Elkaïm, P. Horcajada and M. J. Blanco-Prieto, CrystEngComm, 2015, 17, 456 DOI: 10.1039/C4CE00885E

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