Issue 10, 2014

Explorations of fungal biosynthesis of reduced polyketides – a personal viewpoint

Abstract

This viewpoint on biosynthesis of reduced polyketides in fungi traces evolution of the research area over more than 4 decades. It is a companion to the related articles by two personal and scientific friends with whom there has been free exchange of ideas for over 30 years. Beginning with very rudimentary knowledge about assembly of such natural products, developments using stable isotope labelling and subsequently identification of biosynthetic genes, led to understanding of the processive nature of polyketide formation. Recent expression and isolation of fungal iterative polyketide synthase enzymes has enabled more detailed exploration of the mechanisms of these fascinating molecular machines.

Graphical abstract: Explorations of fungal biosynthesis of reduced polyketides – a personal viewpoint

Article information

Article type
Viewpoint
Submitted
27 iyn 2014
First published
24 iyl 2014

Nat. Prod. Rep., 2014,31, 1253-1259

Explorations of fungal biosynthesis of reduced polyketides – a personal viewpoint

J. C. Vederas, Nat. Prod. Rep., 2014, 31, 1253 DOI: 10.1039/C4NP00091A

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