Multifaceted photocatalysis enables cobalt catalyzed enantioselective C–H activation and APEX reaction for C–N axially chiral molecules

Mainak Koner, Nityananda Ballav, Anirudh J. Varma, Suman Ghosh, Tuhin Mondal, Rositha Kuniyil and Mahiuddin Baidya

Chem. Sci., 2025, 16, 19296
DOI: 10.1039/D5SC05287D

Nickel-catalyzed enantioselective C–H functionalization

Fei Yao and Bing-Feng Shi

Chem. Commun., 2026, 62, 1745
DOI: 10.1039/D5CC06344B

Cp*Co(iii)-catalyzed ortho-alkylation/alkenylation of anilides

Yongqi Yu, Jiajia Yu, Yanqi Li, Mengdan You, Rantao Huang, Weiguang Kong, Ming Chen, Jinjin Bai, Wenguang Li and Ting Li

Org. Biomol. Chem., 2025, 23, 2086
DOI: 10.1039/D4OB01974A

Design of a polymer supported chiral cobalt catalyst for heterogeneous enantioselective C–H activations

Jie Lin, Dingguo Song, Wenji Zhang, Changdi Zheng, Cunwei Zheng, Jiayang Lv, Jun Xue, Weihui Zhong and Fei Ling

Green Chem., 2025, 27, 8251
DOI: 10.1039/D4GC06596D

Atroposelective synthesis of isoquinolinone bearing two distinct C–N axes via cobalt-catalyzed enantioselective C–H activation/annulation

Wenkai Li, Liling Fu, Yongqiang Xu, Yuhan Zhou, Jingping Qu and Baomin Wang

Chem. Commun., 2026, 62, 4276
DOI: 10.1039/D5CC05883J

Enantioselective C–H amidation of sulfondiimines for the synthesis of 1,2,4-benzothiadiazine-1-imines under cobalt catalysis

Ayami Murata, Tomonori Endo, Yuki Hirata, Kosuke Higashida, Tatsuhiko Yoshino and Shigeki Matsunaga

Org. Chem. Front., 2025, 12, 4236
DOI: 10.1039/D5QO00355E

Recent advances in asymmetric C–H bond functionalization enabled by chiral directing groups

Yun Wang, Shuang Wang, Jiayang Wang and Shaojie Lou

Org. Chem. Front., 2026, 13, 713
DOI: 10.1039/D5QO01354B

Enantioselective C–H functionalization: logic and applications in the total synthesis of natural products

Pu-Fan Qian and Bing-Feng Shi

Chem. Sci., 2026, 17, 2969
DOI: 10.1039/D5SC08653A

Enantioselective synthesis of atropisomeric biaryls and heterobiaryls via transition metal-catalyzed cyclization

Shibo Lin, Ya Zou, Yiwen Chu, Junfeng Deng and Lifeng Zhao

Org. Chem. Front., 2026, 13, 2599
DOI: 10.1039/D5QO01492A

Cp*Co(iii)-catalyzed synthesis of isoquinolones via controlled annulation of primary arylamides with internal alkynes

Saksham Mishra, Akanksha Singh Baghel and Amit Kumar

Org. Biomol. Chem., 2025, 23, 427
DOI: 10.1039/D4OB01693A

Metallaelectro-catalyzed alkyne annulations via C–H activations for sustainable heterocycle syntheses

Preeti Kushwaha, Anjali Saxena, Tristan von Münchow, Suman Dana, Biswajit Saha and Lutz Ackermann

Chem. Commun., 2024, 60, 12333
DOI: 10.1039/D4CC03871A

Transition metal-catalyzed cascade C–H activation/cyclization with alkynes: an update on sulfur-containing directing groups

Fen Xu, Shi-Yu Zhang, Ya-Peng Li, Jia-Qi Huo and Fan-Wang Zeng

Chem. Commun., 2025, 61, 1729
DOI: 10.1039/D4CC05807K

Enantioselective C(sp3)–H bond functionalization enabled by CpxM(iii) catalysis (M = Co, Rh, Ir)

Shu-Bin Mou, Mu-Peng Luo, Feifei Fang, Shi Cao, Dong Wu and Shou-Guo Wang

Chem. Sci., 2026, 17, 2990
DOI: 10.1039/D5SC08394J

Unleashing the potentiality of metals: synergistic catalysis with light and electricity

Zhengjia Shen, Jia-Lin Tu and Binbin Huang

Org. Chem. Front., 2024, 11, 4024
DOI: 10.1039/D4QO00797B

Cobalt(III)-Catalyzed Synthesis of Chiral 1,2-Amino Alcohols by C–H Carboamidation

Wilfrido E. Almaraz-Ortiz and Nicolai Cramer

ACS Catal., 2025, 15, 17436
DOI: 10.1021/acscatal.5c05544

Cp*Co(III)-Catalyzed ortho-C–H Alkynylation of Pivalanilides with Bromoalkynes

Yongqi Yu, Jiajia Yu, Mengdan You, Yanqi Li, Heyun Sheng, Rantao Huang, Wenguang Li and Ting Li

J. Org. Chem., 2025, 90, 15074
DOI: 10.1021/acs.joc.5c02098

Construction of Planar-Chiral Macrocyclic Isoquinolinones and Isoquinolines through Cobalt-Catalyzed Atroposelective C−H Annulations

Zhenghao Li, Jie Zhang, Yuhua Duan, Zhineng Chen, Jin Ge, Lina Zhong, Meihua Xin and Guolin Cheng

ACS Catal., 2026
DOI: 10.1021/acscatal.6c00546

Modular Assembly of Chiral Cp* Clones Unlocks Performant Catalysts for Enantioselective C–H Functionalizations

Bram Van Den Bossche and Nicolai Cramer

J. Am. Chem. Soc., 2026, 148, 18468
DOI: 10.1021/jacs.6c05307

Asymmetric Synthesis of Chiral Calix[4]arenes with Both Inherent and Axial Chirality via Cobalt‐Catalyzed Enantioselective Intermolecular C−H Annulation

Pu‐Fan Qian, Gang Zhou, Jia‐Heng Hu, Bing‐Jie Wang, Ao‐Lian Jiang, Tao Zhou, Wen‐Kui Yuan, Qi‐Jun Yao, Jia‐Hao Chen, Ke‐Xin Kong and Bing‐Feng Shi

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202412459

Transition‐Metal‐Catalyzed Convergent Synthesis of Heterocyclic Compounds via CH Activation/Cyclization: An Overview and Summary Toward Terminal Alkynes

Fen Xu, Zi‐Han Wang, Meng‐Yu Sun, Luciano Barboni, Yuan Feng, Huan‐Huan Zhao, Yang Yang and Fan‐Wang Zeng

Eur J Org Chem, 2025, 28
DOI: 10.1002/ejoc.202500651

Asymmetric C(sp3)−H dienylation of thioamides under Cp*Co(III)/chiral acid catalysis

Bholanath Garai, Arka Ghosh, Sayan Dutta, Bholanath Maity, Luigi Cavallo and Basker Sundararaju

Journal of Catalysis, 2026, 456, 116779
DOI: 10.1016/j.jcat.2026.116779

Earth-abundant cobalt-catalyzed enantioselective C-H functionalizations

Taixin Yang, Yanbo Zhang, Yingchao Dou, Dandan Yang and Jun-Long Niu

Sci. China Chem., 2026, 69, 659
DOI: 10.1007/s11426-025-2929-y

Cp*Co(III)-Catalyzed Defluorinative Allylation via Ketone-Directed C–H Activation

Yongqi Yu, Mengdan You, Yanqi Li, Jiajia Yu, Rantao Huang, Heyun Sheng, Wenguang Li and Ting Li

J. Org. Chem., 2025, 90, 16638
DOI: 10.1021/acs.joc.5c02346

Stereocontrolled Construction of Multi-Chiral [2.2]Paracyclophanes via Cobaltaphotoredox Dual Catalysis

Yang Xu, Neeraj Kumar Pandit, Silvia Meraviglia, Philipp Boos, Paula Anna Maria Stark, Max Surke, Regine Herbst-Irmer, Dietmar Stalke and Lutz Ackermann

ACS Catal., 2025, 15, 11716
DOI: 10.1021/acscatal.5c03002

Inherently Chiral Calix[4]Arene Derivatives: Concept and Enantioselective Synthesis

Jia Feng, Long‐Long Xi and Ren‐Rong Liu

Chemistry A European J, 2025, 31
DOI: 10.1002/chem.202502247

Enantioselective Cobalt(III)-Catalyzed [4 + 1] Annulation of Benzamides: Cyclopropenes as One-Carbon Synthons

Lenin Kumar Verdhi, Matthew D. Wodrich and Nicolai Cramer

J. Am. Chem. Soc., 2025, 147, 15041
DOI: 10.1021/jacs.4c16953

A Dual Cobalt‐Photoredox Catalytic Approach for Asymmetric Dearomatization of Indoles with Aryl Amides via C−H Activation

Abir Das, Subramani Kumaran, Harihara Subramanian Ravi Sankar, J. Richard Premkumar and Basker Sundararaju

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202406195

Enantiodivergent Synthesis of 3‐Vinylphthalides via Rh‐Catalyzed C─H Annulation: Experimental and Computational Studies

Marimuthu Bakkiyaraj, Muthu P. Guruprakash and Pazhamalai Anbarasan

Chemistry A European J, 2026, 32
DOI: 10.1002/chem.202502827

Co/Salox-Catalyzed Enantioselective C–H Annulation for One-Step Generation of C–N Axial and C Central Chirality

Sarthi, Devesh Chandra, Rohit Kumar, Akhilesh K. Sharma, Miho Isegawa and Upendra Sharma

Org. Lett., 2026, 28, 6177
DOI: 10.1021/acs.orglett.6c00983

Catalytic Enantioselective Synthesis of Planar-Chiral Cyclophanes via a Chiral Octahedral Cobalt(III)-Templated C–H Macrocyclization

Bing-Jie Wang, Tian-Yu Jiang, Yao-Le Jiang, Xu Wu, Qi-Jun Yao and Bing-Feng Shi

J. Am. Chem. Soc., 2025, 147, 45785
DOI: 10.1021/jacs.5c18900

Desymmetrization and Atroposelective Cobalt Catalyzed C–H Annulation of Phosphinic Amides with Ynamides

Somratan Sau, Abid Ali, Koushik Pradhan, Paushali Naskar, Vincent Gandon and Akhila K. Sahoo

Org. Lett., 2026, 28, 3236
DOI: 10.1021/acs.orglett.6c00278

Parametrization of κ2-N,O-Oxazoline Preligands for Enantioselective Cobaltaelectro-Catalyzed C–H Activations

Suman Dana, Neeraj Kumar Pandit, Philipp Boos, Tristan von Münchow, Sven Erik Peters, Sven Trienes, Laura Haberstock, Regine Herbst-Irmer, Dietmar Stalke and Lutz Ackermann

ACS Catal., 2025, 15, 4450
DOI: 10.1021/acscatal.5c00250

Cobalt-Catalyzed Enantioselective and Diastereodivergent Construction of C–N Atropisomers

Abir Das, Subramani Kumaran, Pritam Maity, J. Richard Premkumar and Basker Sundararaju

J. Am. Chem. Soc., 2025, 147, 26226
DOI: 10.1021/jacs.5c03776

Enantioselective Cobaltaphotoredox-Catalyzed C–H Activation

Yang Xu, Ye Lin, Simon L. Homölle, João C. A. Oliveira and Lutz Ackermann

J. Am. Chem. Soc., 2024, 146, 24105
DOI: 10.1021/jacs.4c08459

A Dual Cobalt‐Photoredox Catalytic Approach for Asymmetric Dearomatization of Indoles with Aryl Amides via C−H Activation

Abir Das, Subramani Kumaran, Harihara Subramanian Ravi Sankar, J. Richard Premkumar and Basker Sundararaju

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202406195

Mechanistic Investigations of Cobalt-Catalyzed, Aminoquinoline-Directed C(sp2)–H Bond Functionalization

Lukass Lukasevics, George N. Oh, Xiqu Wang, Liene Grigorjeva and Olafs Daugulis

J. Am. Chem. Soc., 2025, 147, 2476
DOI: 10.1021/jacs.4c13086

Enantioselective C–H Functionalization Reactions Enabled by Cobalt(III)‐Centered Chiral Pockets

Ming‐Yu Zhong, Yinwu Li, Jia‐Hao Chen, Shi‐Yu Mao, Tian‐Yu Jiang, Zhuofeng Ke, Qi‐Jun Yao and Bing‐Feng Shi

Angewandte Chemie, 2026
DOI: 10.1002/ange.9100826

Nickel(II)/Salox-Catalyzed Enantioselective C–H Functionalization

Jia-Hao Chen, Qi-Jun Yao, Ming-Yu Zhong, Tian-Yu Jiang, Fan-Rui Huang, Xiang Li and Bing-Feng Shi

ACS Cent. Sci., 2025, 11, 127
DOI: 10.1021/acscentsci.4c02049

Recent Advances in Asymmetric C—H Bond Functionalization Using Oxidizing Directing Groups

Shuang Wang, Yangjie Mao, Shaojie Lou and Danqian Xu

Chinese Journal of Organic Chemistry, 2025, 45, 1961
DOI: 10.6023/cjoc202409023

Co(III)-Catalyzed Three-Component Cascade for the Synthesis of α-Quaternary Acyclic Nitriles via C–H Bond Activation

Priyambada Prusty and Masilamani Jeganmohan

Org. Lett., 2025, 27, 14247
DOI: 10.1021/acs.orglett.5c04508

Catalytic C–C Bond Formation via Aromatic C–H Bond Cleavage Using Low-Valent Iron-Phosphine Complexes

Fumitoshi Kakiuchi and Takuya Kochi

Synlett, 2025, 36, 3000
DOI: 10.1055/a-2630-1454

Catalytic Enantioselective [4+1]-Annulation of Carboxylic Acids with Cyclopropenes

Marimuthu Bakkiyaraj and Pazhamalai Anbarasan

Org. Lett., 2025, 27, 1638
DOI: 10.1021/acs.orglett.4c04827

Progress on Cobalt-Catalyzed C(sp2)—H Activation for the Construction of Nitrogen-Containing Benzo Heterocycles

Xun Tian, Guogang Deng and Xiaodong Yang

Chinese Journal of Organic Chemistry, 2025, 45, 655
DOI: 10.6023/cjoc202404038

Cobalt‐Catalyzed Regio, Diastereo, and Enantioselective C–H Annulation of Aminoquinoline Amides with Internal Alkynes for the Construction of Diaxes

Xi Wu, Qingyu Tian, Jin Ge, Yaopeng Liu, Zhenghao Li, Jie Zhang and Guolin Cheng

Chin. J. Chem., 2025, 43, 2669
DOI: 10.1002/cjoc.70174

Enantioselective C–H Functionalization Reactions Enabled by Cobalt(III)‐Centered Chiral Pockets

Ming‐Yu Zhong, Yinwu Li, Jia‐Hao Chen, Shi‐Yu Mao, Tian‐Yu Jiang, Zhuofeng Ke, Qi‐Jun Yao and Bing‐Feng Shi

Angew Chem Int Ed, 2026
DOI: 10.1002/anie.9100826

Asymmetric Synthesis of Chiral Calix[4]arenes with Both Inherent and Axial Chirality via Cobalt‐Catalyzed Enantioselective Intermolecular C−H Annulation

Pu‐Fan Qian, Gang Zhou, Jia‐Heng Hu, Bing‐Jie Wang, Ao‐Lian Jiang, Tao Zhou, Wen‐Kui Yuan, Qi‐Jun Yao, Jia‐Hao Chen, Ke‐Xin Kong and Bing‐Feng Shi

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202412459

Mechanistic Investigations on Cp*CoIII-Catalyzed Quinoline Transfer Hydrogenation with Formic Acid

Nidhi Garg, Pardeep Dahiya, Sonia Mallet-Ladeira, Rinaldo Poli and Basker Sundararaju

ACS Catal., 2024, 14, 17556
DOI: 10.1021/acscatal.4c05271