An endoplasmic reticulum-targeting iridium(iii) complex induces immunogenic cell death in melanoma cells and enhances anti-PD-1 immunotherapy by remodeling tumor microenvironment

Yi Rong, Zhongxian Fan, Zhijie Yu, Li Wei, Han Shen, Huaiyi Huang, Xiaojuan Hao, Zizhuo Zhao and Jinquan Wang

Inorg. Chem. Front., 2023, 10, 5278
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Metal-based immunogenic cell death inducers for cancer immunotherapy

Jiao Xia Zou, Meng Rui Chang, Nikita A. Kuznetsov, Jia Xuan Kee, Maria V. Babak and Wee Han Ang

Chem. Sci., 2025, 16, 6160
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Mn(iii)-mediated carbon-centered radicals generate an enhanced immunotherapeutic effect

Jiaxuan Li, Baifei Hu, Zelong Chen, Jiahui Li, Wenjuan Jin, Yi Wang, Yichen Wan, Yinghua Lv, Yuxin Pei, Hongtao Liu and Zhichao Pei

Chem. Sci., 2024, 15, 765
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Organometallic anti-tumor agents: targeting from biomolecules to dynamic bioprocesses

Kun Peng, Yue Zheng, Wei Xia and Zong-Wan Mao

Chem. Soc. Rev., 2023, 52, 2790
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Anticancer gold complexes: Controlled activation, precision targeting and beyond

Yuan Wang, Sinan Zhong and Taotao Zou

Journal of Inorganic Biochemistry, 2026, 280, 113315
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Gold catalysis in organic synthesis: fifteen years of research in India

Debasish Mandal, Anil Kumar and Nitin T. Patil

Proc.Indian Natl. Sci. Acad., 2022, 88, 501
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Recent advances in the development of metallodrugs for cancer chemoimmunotherapy

Fangmian Wei, Jinzhe Liang, Xing-Can Shen, Yihang Pan, Yulong He and Hui Chao

Coordination Chemistry Reviews, 2025, 526, 216319
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Mitophagy: A double-edged sword in tumor cell death regulation and therapeutic response

Tong Chu, Zifeng Huang and Wenzhe Ma

Biochemical and Biophysical Research Communications, 2025, 777, 152254
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Modulating the Chemical Reactivity of Gold Complexes in Living Systems: From Concept to Biomedical Applications

Jia Jiang, Xiaolin Xiong and Taotao Zou

Acc. Chem. Res., 2023, 56, 1043
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A Machine Learning-Based Classification of Immunogenic Cell Death Regulators and Characterisation of Immune Microenvironment in Acute Ischemic Stroke

Mengying Wang, Guolian Wei, Shaorui Gu, Zhengyuan Huo, Xue Han and Woon-Man Kung

International Journal of Clinical Practice, 2023, 2023, 1
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Rhodium-based metallodrugs for biological applications: current status and future perspectives

Wang Xiang, Suisui He, Tao Kuang, Jun Yin, Bin Hu, Chao Sun, Juan He, Jun Wang, Cui-Yun Yu and Hua Wei

Materials Today Bio, 2025, 33, 101941
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Substituent Effect of Superhalogens on the Metallodrug IMeAuCl: A DFT Study

Xin Cheng, Bin Liu, Jing‐Hua Chen and Wei‐Ming Sun

ChemPhysChem, 2025, 26
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Novel gold-based complex GC7 suppresses cancer cell proliferation via impacting energy metabolism mediated by mitochondria

Qingbin Cui, Wenwen Ding, Bingling Luo, Wenhua Lu, Peng Huang and Shijun Wen

Bioorganic & Medicinal Chemistry, 2024, 112, 117897
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Application of photodynamic activation of prodrugs combined with phototherapy in tumor treatment

Yining Du, Jingyuan Zhao, Shuai Li and Hong Yuan

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Towards Understanding the Molecular Mechanisms of Immunogenic Cell Death

Xiaolin Xiong, Yuan Wang and Taotao Zou

ChemBioChem, 2023, 24
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Cyclometalated iridium(III) complex based on isoquinoline alkaloid synergistically elicits the ICD response and IDO inhibition via autophagy-dependent ferroptosis

Yuan Lu, Shan-Shan Wang, Meng-Ya Li, Rong Liu, Meng-Fan Zhu, Liang-Mei Yang, Feng-Yang Wang, Ke-Bin Huang and Hong Liang

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New rhodium(III)-triphenylphosphine complexes with 5-halogenate-8-hydroxyquinoline as ligands: synthesis, characterization, cytotoxicity, and mechanism of action

Zhen-Feng Wang, Xiao-Qiong Huang, Run-Chun Wu, Shu-Hua Zhang and Guangzhao Li

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A dinuclear gold(I) complex with bis(N-heterocyclic carbene) ligands potentiated immune responses against liver cancer via ROS-driven endoplasmic reticulum stress and ferroptosis

Qiuyue Lu, Min Shan, Jiaqi Yang, Zhongren Xu, Yueyue Lei and Wukun Liu

Chinese Chemical Letters, 2025, 36, 110940
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Oxoisoaporphine Alkaloid Iridium(III) Derivative: An Immunogenic Cell Death Inducer That Engages the Autophagy-Dependent Regulator Cathepsin D

Yuan Lu, Feng-Yang Wang, Matthew S. Levine, Hai-Rong Shi, Yuan Wang, Xiaolin Xiong, Liang-Mei Yang, Ya-Qian Shi, Taotao Zou, Jonathan L. Sessler, Hong Liang and Ke-Bin Huang

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Solvothermal domino synthesis of an ER-targeted iron(II) complex for inducing immunogenic cell death

Ning Tian, Haoyu Ju, Qian Hu, Qifeng Hou, Yiping Lu, Yu Liu, Jinmei Huang, Zhong-Hong Zhu, Bin Zhang, Jin Huang and Ming-Hua Zeng

Chinese Chemical Letters, 2026, 37, 111038
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Subcellular Photocatalysis Enables Tumor-Targeted Inhibition of Thioredoxin Reductase I by Organogold(I) Complexes

Moyi Liu, Haitao Liu, Yan Yang, Xiaolin Xiong and Taotao Zou

J. Am. Chem. Soc., 2025, 147, 15719
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Leveraging Immunogenic Cell Death to Enhance the Immune Response against Malignant Pleural Mesothelioma Tumors

Meng Rui Chang, Egor M. Matnurov, Chengnan Wu, Jemma Arakelyan, Ho-Jung Choe, Vladimir Kushnarev, Jian Yu Yap, Xiu Xuan Soo, Mun Juinn Chow, Walter Berger, Wee Han Ang and Maria V. Babak

J. Am. Chem. Soc., 2025, 147, 7908
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Engineering the electronic structure of Fe-MoO2@PEG to increase sonodynamic and multi-nanozyme activities for anticancer therapy

Rongrong Mu, Wenhui Song, Zili Li, Yuting Pan, Jingwei Liu, Fengyu Qu and Huiming Lin

Journal of Colloid and Interface Science, 2026, 701, 138626
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Cu(II) complex that synergistically potentiates cytotoxicity and an antitumor immune response by targeting cellular redox homeostasis

Ke-Bin Huang, Feng-Yang Wang, Yuan Lu, Liang-Mei Yang, Nian Long, Shan-Shan Wang, Zhiying Xie, Matthew Levine, Taotao Zou, Jonathan L. Sessler and Hong Liang

Proc. Natl. Acad. Sci. U.S.A., 2024, 121
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Investigation of the potential anticancer immune response for gold compounds

Mianli Bian, Zhenfan Wen, Jing Shi and Wukun Liu

Chinese Chemical Letters, 2026, 112596
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