Synergistic applications of cyclodextrin-based systems and metal–organic frameworks in transdermal drug delivery for skin cancer therapy

Thomas Scattolin, Giovanni Tonon, Eleonora Botter, Viviana Claudia Canale, Mahdi Hasanzadeh, Denise Maria Cuscela, Annamaria Buschini, Atefeh Zarepour, Arezoo Khosravi, Marco Cordani, Flavio Rizzolio and Ali Zarrabi

J. Mater. Chem. B, 2024, 12, 3807
DOI: 10.1039/D4TB00312H

Ex vivo transdermal delivery of 3H-labelled atovaquone solid drug nanoparticles: a comparison of topical, intradermal injection and microneedle assisted administration

Sam Morris, Mark Long, Alison Savage, Andrew Owen, Steve Rannard and Helen Cauldbeck

Nanoscale Adv., 2023, 5, 6400
DOI: 10.1039/D3NA00454F

Carbon quantum dots as transcutaneous drug carriers: mechanisms, challenges and prospects

Veena Venugopal, B. Siva Kumar, S. Giridhar Reddy and Sai Manohar Thota

RSC Adv., 2026, 16, 10689
DOI: 10.1039/D5RA08722H

Polymeric Membrane-Based Systems in Transdermal Drug Delivery

Laura Donato and Paola Bernardo

Polymers, 2026, 18, 376
DOI: 10.3390/polym18030376

Two—Dimensional Materials as Antioxidants and Sunscreen Agents in Cosmetics

Xuexue Pan, Rongfei Yu, Jingyi Wu, Jianrong Liang, Weiyuan Huang, Rongyue Huang, Wenkai Li, Yuanlin Xie, Yi Zhao, Yawei Huang, Jiayi Wu, Jinjie Xie, Zhimin Chen, Lu Zhang, Meiyu Wu, Yonggan Fang, Rong Hu and Jianhui Zhang

Braz J Phys, 2025, 55
DOI: 10.1007/s13538-025-01813-x

Preparation and evaluation of citalopram novasomal vesicles as a transdermal analgesic drug delivery

Fereshte Haftan, Katayoun Morteza-Semnani, Jafar Akbari, Mohammad Seyedabadi, Maryam Ghasemi and Majid Saeedi

Drug Deliv. and Transl. Res., 2026
DOI: 10.1007/s13346-026-02084-y

Transformative Impact of Nanocarrier‐Mediated Drug Delivery: Overcoming Biological Barriers and Expanding Therapeutic Horizons

Minhye Kim, Myeongyeon Shin, Yaping Zhao, Mrinmoy Ghosh and Young‐Ok Son

Small Science, 2024, 4
DOI: 10.1002/smsc.202400280

Nanotechnological reprogramming of the pathological skin microenvironment in scar formation and atopic dermatitis

Tae-Hyeong Kim, Seungyong Shin and Wooram Park

J. Pharm. Investig., 2026
DOI: 10.1007/s40005-026-00809-2

Transdermal administration of farnesol-ethosomes enhances the treatment of cutaneous candidiasis induced by Candida albicans in mice

Ting Shen, Baocheng Tian, Wei Liu, Xuesong Yang, Qi Sheng, Mengxin Li, Haiyan Wang, Xiuwen Wang, Huihui Zhou, Yanchun Han, Chen Ding, Sixiang Sai and Renato Kovacs

Microbiol Spectr, 2024, 12
DOI: 10.1128/spectrum.04247-23

Topical nanoparticles for the treatment of skin cancer: Present concerns and challenges

Pritipragatika Nayak, Surya Kanta Swain, Itishree Jogamaya Das, Sushree Sambita Swain, Bikash Ranjan Jena and Himansu Bhusan Samal

Journal of Drug Delivery Science and Technology, 2025, 114, 107566
DOI: 10.1016/j.jddst.2025.107566

Optimization and preparation of doxycycline-loaded chitosan nanoparticles using Box-Behnken design for better diabetic wound healing

Harish Bhardwaj, Ram Kumar Sahu and Rajendra Kumar Jangde

Journal of Pharmaceutical Sciences, 2025, 114, 1035
DOI: 10.1016/j.xphs.2024.11.014

Metformin‐loaded silver nanoparticles tailored with their in vitro, ex vivo and in silico characterization modulated via quality‐by‐design approach

Sumanta Sarkar, Rishika Singhal, Manoj Kumar Sarangi, Goutam Rath and L. D. Patel

J Chinese Chemical Soc, 2026, 73, 118
DOI: 10.1002/jccs.70114

Biodegradable polymer casting films for drug delivery and cell culture

Anastasiya V. Murueva, Alexey E. Dudaev, Ekaterina I. Shishatskaya, Fares D.E. Ghorabe, Ivan V. Nemtsev, Anna V. Lukyanenko and Tatiana G. Volova

Giant, 2024, 19, 100314
DOI: 10.1016/j.giant.2024.100314

Modified Phospholipid Vesicular Gel for Transdermal Drug Delivery: The Influence of Glycerin and/or Ethanol on Their Lipid Bilayer Fluidity and Penetration Characteristics

Marwa H. Abdallah, Mona M. Shahien, Hemat El-Sayed El-Horany and Enas Haridy Ahmed

Gels, 2025, 11, 358
DOI: 10.3390/gels11050358

Current issues in optical monitoring of drug delivery via hair follicles

Yulia I. Svenskaya, Roman A. Verkhovskii, Sergey M. Zaytsev, Juergen Lademann and Elina A. Genina

Advanced Drug Delivery Reviews, 2025, 217, 115477
DOI: 10.1016/j.addr.2024.115477

Innovative Fluorescent Polymers in Niosomal Carriers: A Novel Approach to Enhancing Cancer Therapy and Imaging

Selay Tornaci, Merve Erginer, Umut Bulut, Beste Sener, Elifsu Persilioglu, İsmail Bergutay Kalaycilar, Emine Guler Celik, Hasret Yardibi, Pinar Siyah, Oguzhan Karakurt, Ali Cirpan, Baris Gokalsin, Ahmet Murat Senisik and Firat Baris Barlas

Macromolecular Bioscience, 2024
DOI: 10.1002/mabi.202400343

Recent Advancements in Nanopharmaceuticals for Novel Drug Delivery Systems

Kai Bin Liew, Ee Va Koh, Xue Er Kong, Nurdina Aleyah Ismail, Rabiatul Adawiyah Abu Bakar, Phei Er Kee, Syed Haroon Khalid and Hiu Ching Phang

PNT, 2025, 13, 271
DOI: 10.2174/0122117385324246240826042254

Self-Assembled Skin-Penetrating Peptides with Controlled Supramolecular Properties for Enhanced Transdermal Delivery

Jeon Hyeong Kang, Jieun Kim, Jae Yun Lee, DongHyun Kang, Hyun Jin Kim, Kyobum Kim and Woo-jin Jeong

Biomacromolecules, 2024, 25, 436
DOI: 10.1021/acs.biomac.3c01065

Nanocosmeceuticals for Dermatological and Aesthetic Applications: Bridging Material Innovation with Clinical and Regulatory Translation

Tianzhi Zhao, Wenyao Zhen, Xiaoyuan Chen and Jingjing Zhang

ACS Nano Med., 2026, 1, 302
DOI: 10.1021/acsnanomed.5c00046

Molecular insights into the controlled release process of cyclodextrin-resveratrol inclusion complexes in the stratum corneum

Xindong Yu, Shasha Liu, Ying Li and Shiling Yuan

Colloids and Surfaces B: Biointerfaces, 2025, 253, 114725
DOI: 10.1016/j.colsurfb.2025.114725

A Self‐Assembled Transdermal Nanomedicines Incorporating Pendant Disulfides for Non‐Invasive, Synergistic Treatment of Melanoma

Junjie Zhang, Changkun Peng, Shuya Liu, Zhijie Lian, Jie Zhou, Jingying Li and Huanghao Yang

Adv Healthcare Materials, 2024, 13
DOI: 10.1002/adhm.202402685

Dual drug co-encapsulation into liposomes and liposome-derived nanosystems for improved synergistic treatment of skin diseases

Sara Rodrigues, Francisco Veiga, Ana Cláudia Paiva-Santos and Patrícia C. Pires

Drug Deliv. and Transl. Res., 2026, 16, 439
DOI: 10.1007/s13346-025-02016-2

Application of Inorganic Nanomaterials in Transdermal and Topical Medications: Influential Parameters, Opportunities and Challenges

Morteza Servatan, Pelin Mutlu, Suna Ertunç, Soroush Sanaeifard, Birgütay Şahin and Zeynep Yilmazer-Hitit

Comments on Inorganic Chemistry, 2025, 45, 88
DOI: 10.1080/02603594.2024.2323450

Liposomal formulation of a vitamin C derivative: a promising strategy to increase skin permeability

Alejandro Llamedo, Pablo Rodríguez, Carolina de Passos, Sandra Freitas-Rodriguez, Ana M. Coto, Raquel G. Soengas and Rebeca Alonso-Bartolomé

Journal of Liposome Research, 2025, 35, 197
DOI: 10.1080/08982104.2025.2466449

Nanoparticle-based flavonoid therapeutics: Pioneering biomedical applications in antioxidants, cancer treatment, cardiovascular health, neuroprotection, and cosmeceuticals

Hadeer M. Morsy, Mohamed Y. Zaky, Nour Y.S. Yassin and Ashraf Y.Z. Khalifa

International Journal of Pharmaceutics, 2025, 670, 125135
DOI: 10.1016/j.ijpharm.2024.125135

Ferulic Acid: A Comprehensive Review

Jaganathan R Purushothaman and Md. Rizwanullah

Cureus, 2024
DOI: 10.7759/cureus.68063

Recent advances in delivery of transdermal nutrients: A review

Ling Fan, Jihong Huang and Sen Ma

Experimental Dermatology, 2024, 33
DOI: 10.1111/exd.14966

Development of propranolol loaded SLN for transdermal delivery: in-vitro characterization and skin deposition studies

Eskandar Moghimipour, Mohammadamin Khazali, Behzad Sharif MakhmalZadeh, Maryam Abedini Baghbadorani, Ali Zangeneh, Somayeh Sohrabi, Fereshteh Nejaddehbashi, Fatemeh Hajipour and Somayeh Handali

Therapeutic Delivery, 2025, 16, 205
DOI: 10.1080/20415990.2025.2458451

HPMA polymers as functional excipients in dermal nanoformulations of imiquimod

Eliška Kurfiřtová, Stanislav Chvíla, Nikola Strnádková, Vendula Janoušková, Petr Chytil, Tomáš Etrych and Jarmila Zbytovská

International Journal of Pharmaceutics: X, 2026, 11, 100486
DOI: 10.1016/j.ijpx.2026.100486

Progress in Lipid and Inorganic Nanocarriers for Enhanced Skin Drug Delivery

Lamyaa Albakr, Hongyuan Du, Xiyuan Zhang, Himanshu Kathuria, Ahmed Fahmi Anwar‐Fadzil, Nial J. Wheate and Lifeng Kang

Advanced NanoBiomed Research, 2024, 4
DOI: 10.1002/anbr.202400003

Nanotechnology-Driven Transdermal System for Loxapine Succinate: A Novel Strategy To Improve Pharmacokinetics and Therapeutics in Psychotic Disorders

Gaurav Ghumare, Pramod Salve, Ujban MD Hussain, Amol Tatode, Mohammad Qutub, Tanvi Premchandani and Samiksha Tammewar

J Pharm Innov, 2025, 20
DOI: 10.1007/s12247-025-10131-3

Advances in nanoparticle-mediated transdermal delivery of nucleic acids as therapy of skin disorders and cancer

Fatemeh Mokhles, Juan Gonzalez-Valdivieso, Mohammad Amin Moosavi and Marco Cordani

Current Opinion in Biomedical Engineering, 2025, 35, 100611
DOI: 10.1016/j.cobme.2025.100611

Microneedle Mediated Gas Delivery for Rapid Separation, Enhanced Drug Penetration, and Combined Therapy

Ziyang Zheng, Ting Zhou, Hongluo Li, Jade Jillian Xian Lan Zeng, Yanping Fu, Chao Lu, Tingting Peng, Chuanbin Wu and Guilan Quan

Pharmaceutics, 2025, 17, 1576
DOI: 10.3390/pharmaceutics17121576

Nanoemulgel-based delivery of 3-O-Acetyl-11-Keto-β-Boswellic Acid and basil oil for enhanced transdermal efficacy: In vitro anti-inflammatory and antioxidant assessment

Sudhanshu Mishra, Lalit Kumar Tyagi and Kanchan Kohli

Letters in Drug Design & Discovery, 2025, 22, 100152
DOI: 10.1016/j.lddd.2025.100152

Recent Approaches for the Topical Treatment of Psoriasis Using Nanoparticles

Krisztina Bodnár, Pálma Fehér, Zoltán Ujhelyi, Ildikó Bácskay and Liza Józsa

Pharmaceutics, 2024, 16, 449
DOI: 10.3390/pharmaceutics16040449

Deep-insights: Nanoengineered gel-based localized drug delivery for arthritis management

Anitha Sriram, Harshada Ithape and Pankaj Kumar Singh

Asian Journal of Pharmaceutical Sciences, 2025, 20, 101012
DOI: 10.1016/j.ajps.2024.101012

Dermal Toxicity of Nanoparticles: A Review of Recent Progress

Md. Abu Rayhan, Saleh Ahmed, Md Simul Bhuiya, Md Salman Shakil and Shihab Uddin

Chem. Res. Toxicol., 2026
DOI: 10.1021/acs.chemrestox.5c00416

Poly(lactic acid)/poly(arginine) nanoparticles loaded with resveratrol: antioxidant potential and biocompatibility

Daianne Leandro Padroni de Souza and Lívia Rodrigues de Menezes

Journal of Biomaterials Science, Polymer Edition, 2026, 1
DOI: 10.1080/09205063.2026.2624425

Understanding Microemulsions and Nanoemulsions in (Trans)Dermal Delivery

Jasmine Musakhanian and David W. Osborne

AAPS PharmSciTech, 2025, 26
DOI: 10.1208/s12249-024-02997-2

Preparation, characterization and efficacy of hyaluronic acid-modified two targeted liposomes for ectoin delivery to the skin

Li Xu, Zhenlin Shang, Dongxu Liu, Caiyun Zhao, Chengke Zhao, Xiaojing Pei and Ze Zhang

Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2025, 719, 137013
DOI: 10.1016/j.colsurfa.2025.137013

Exploring Elastic Lipid Nanovesicles for Enhanced Skin Permeation of Whole Plant Extract: A Comprehensive Investigation

Rahul Maheshwari, Mayank Sharma and Sankha Bhattacharya

J Biomed Mater Res, 2025, 113
DOI: 10.1002/jbm.b.35527

Innovations in Non-Invasive Biomarker Discovery: Unraveling the Molecular Landscapes of Human Skin

Tamer A. Addissouky

Biomedical Materials & Devices, 2025
DOI: 10.1007/s44174-025-00596-8

Twin defect-rich Pt ultrathin nanowire nanozymes alleviate inflammatory skin diseases by scavenging reactive oxygen species

He Zhao, Han Zhao, Mengfan Li, Yan Tang, Xin Xiao, Yisheng Cai, Fanping He, Hongwen Huang, Yiya Zhang and Ji Li

Redox Biology, 2024, 70, 103055
DOI: 10.1016/j.redox.2024.103055

Colloidal drug delivery systems for infectious diseases of skin

Sopan Nangare, Varda Joshi, Shrikant Magdum, Riya Patil and Vishin Patil

Current Opinion in Pharmacology, 2025, 83, 102536
DOI: 10.1016/j.coph.2025.102536

Transdermal Drug Delivery of Flavonoid Compounds and Nanoparticles: Uptake, Interaction, Mechanism, and QSAR Studies

Zhaoli Jiang, Hua Shao, Ying Li and Shiling Yuan

Langmuir, 2025, 41, 20030
DOI: 10.1021/acs.langmuir.5c02144

Cell-Penetrating Peptide-engineered Solid Lipid Nanoparticles for Enhanced Endocytotic Internalization and Transdermal Penetration

Minsoo Kang, Wooseop Hwang, Jongryeol Yang, Seulgi Kim, Saetbyeol Jeon, Minjoo Noh, Jihyun Lee, Jun Bae Lee, YongJoo Kim and Jin Woong Kim

ACS Appl. Nano Mater., 2025, 8, 19192
DOI: 10.1021/acsanm.5c02987

Ultra-Flexible Liposomal Gels Versus Pressure-Sensitive Adhesive Transdermal Patches: A Comparative Pharmacokinetic Study for Effective Management of Parkinson’s Disease

Afridi Chabru, Pramod Salve, Mohammad Qutub, Ujban Hussain, Amol Tatode, Samiksha Tammewar, Sameer Sheikh and Tanvi Premchandani

J Pharm Innov, 2026, 21
DOI: 10.1007/s12247-025-10268-1

Nanostructured materials for breast cancer therapeutics enhancing drug delivery through nanofibers, nano-mesh, and nanoflowers

Navya Aggarwal, Shreya Gupta, Shinjini Sen, Tanmay J. Urs and Banashree Bondhopadhyay

Next Nanotechnology, 2025, 8, 100159
DOI: 10.1016/j.nxnano.2025.100159

Tuning Supramolecular Hydrogels with Surfactant‐Based Organic Nanoparticles for Drug Delivery

Dinesh Kumar Duraisamy, Puchalapalli Saveri, Abhijit P. Deshpande, Vandhana Anumaiya, Suresh Kumar Anandasadagopan and Ganesh Shanmugam

ChemPlusChem, 2026, 91
DOI: 10.1002/cplu.70129

Brucine-Loaded Nickel oxide/Sodium alginate/Polyethylene glycol Nanocomposites Mitigates Inflammatory Responses and Oxidative stress in imiquimod-induced Psoriasis-Like Skin Inflammation in Mice

Shuang Wang, Abdurahman Hajinur Hirad, Abdullah A. Alarfaj and Quan Shi

Journal of Drug Delivery Science and Technology, 2025, 104, 106521
DOI: 10.1016/j.jddst.2024.106521

Microneedle-assisted nanomedicine: Emerging strategies for transdermal drug delivery

Atefeh Zarepour, Asieh Soozanipour and Arezoo Khosravi

Current Opinion in Biomedical Engineering, 2025, 35, 100602
DOI: 10.1016/j.cobme.2025.100602

Development and evaluation of the novel chitosan-based 1% clindamycin & 2.5% benzoyl peroxide transferosomal gel for topical acne treatment

Uzma Nayeem, Aakriti Garg, Ayan Kumar Das, Neetu Shree, Yasmeen, Yasmin Sultana, Shaista Ahmed and Mohd Ashif Khan

Journal of Drug Delivery Science and Technology, 2023, 89, 105002
DOI: 10.1016/j.jddst.2023.105002

Multi-hierarchical nanoparticles with tunable core by emulsion polymerization processes

Jakes Udabe, Neha Tiwari, Agustin Picco, Cristián Huck-Iriart, Carlos Escudero and Marcelo Calderón

European Polymer Journal, 2023, 201, 112566
DOI: 10.1016/j.eurpolymj.2023.112566

Intelligent transdermal nanoparticles as synergizing advanced delivery systems for precision therapeutics

Zhouying Guo, Yi'nan Zhang, Man Zhao, Wenyuan Zhang, Xiaofang Li, Fang Zhou, Haisheng Peng, Qun Wang and Zhiwei Chen

Materials Today Bio, 2025, 34, 102220
DOI: 10.1016/j.mtbio.2025.102220

Percutaneous permeation, distribution and absorption of quantum dots

Varsha Sahu and Sunit Kumar Sahoo

Next Nanotechnology, 2026, 9, 100368
DOI: 10.1016/j.nxnano.2026.100368

Polymer homologue-mediated formation of hydrogel microneedles for controllable transdermal drug delivery

Xinwei Fu, Hong Xian, Chuanlan Xia, Yingqi Liu, Shan Du, Bo Wang, Peng Xue, Bin Wang and Yuejun Kang

International Journal of Pharmaceutics, 2024, 666, 124768
DOI: 10.1016/j.ijpharm.2024.124768

Interface‐Engineered Nanocarriers for Translational and Patient‐Centric Topical Therapy in Psoriasis

Vivek Singh, Urushi Rehman, Taha Alqahtani, Humood Al Shmrany, Garima Gupta, Khang Wen Goh and Prashant Kesharwani

Drug Development Research, 2026, 87
DOI: 10.1002/ddr.70213

Emerging Delivery Systems for Enabling Precision Nucleic Acid Therapeutics

Xiaochun Bian, Liping Zhou, Zhiwei Luo, Guotao Liu, Zhongci Hang, Haohao Li, Fengyong Li and Yongqiang Wen

ACS Nano, 2025, 19, 4039
DOI: 10.1021/acsnano.4c11858

Chrysin-Loaded Hybrid Nanoparticles for Enhanced Anti-Psoriatic Activity in Imiquimod-Induced Psoriasis Rat Model

Taison Jamatia, Malay K. Das, Sentu Das and Balisa Mosisa Ejeta

J Pharm Innov, 2026, 21
DOI: 10.1007/s12247-026-10668-x

Topical Application onto the Eyelid Skin: Is it a Feasible Delivery Route of Ophthalmic Drugs?

Larysa Grygor’yeva, Manuela Colla Carvalheiro and Sandra Simoes

MRMC, 2025, 25, 521
DOI: 10.2174/0113895575358373241220043138

Nanoparticle-based drug carriers in transdermal and topical delivery: An in vivo review of anti-inflammatory efficacy

Antrea-Maria Athinodorou, Eirini Papanikolaou, Panagiota Zygouri, Konstantinos Spyrou, Ioannis Panagiotis Athinodorou, Patra Vezyraki, Haralambos Stamatis, Konstantinos I. Tsamis, Lampros Lakkas, Georgios S. Markopoulos, Dimitrios Peschos and Yannis V. Simos

Biochemical Pharmacology, 2026, 244, 117567
DOI: 10.1016/j.bcp.2025.117567

SLN and chitosan nano-delivery systems for antibacterial effect of black seed ( Nigella sativa) oil against S. aureus

Mahdis Payamifard, Mehran Nemattalab, Leila Rezaie Shirmard and Zahra Hesari

International Journal of Environmental Health Research, 2025, 35, 991
DOI: 10.1080/09603123.2024.2378103

Development and In-Vitro Categorization of Cilnidipine-loaded Transdermal Patches: Design, Evaluation, and Performance Assessment

Lalchand D Devhare, Sachin Hiradeve, Vaibhav Uplanchiwar, Vinod Thakare, Namrata S Mane, Pravinkumar B Suruse and Kurtika Channe

J Pharm Innov, 2026, 21
DOI: 10.1007/s12247-026-10583-1

Biomaterials for Improving Skin Penetration in Treatment of Skin Cancer

Davide Secci, Andrew Urquhart, Vasileios Bekiaris and Katrine Qvortrup

JFB, 2026, 17, 39
DOI: 10.3390/jfb17010039

Advances in Functionalization of Bioresorbable Nanomembranes and Nanoparticles for Their Use in Biomedicine

Ahammed H. M. Mohammed-Sadhakathullah, Sofia Paulo-Mirasol, Juan Torras and Elaine Armelin

IJMS, 2023, 24, 10312
DOI: 10.3390/ijms241210312

Nanoparticle-Based Targeted Drug Delivery Systems for Allergic Rhinitis: A Comprehensive Review

Yuenan Wang, Yang Zhou, Boshen Liang, Shuoming Li, Zhenning Wang, Xiaodong Yan, Yiqing Gao, Tiangang Li, Qiong Qin, Shaoli Yang, Fang Guo and Jian Nie

IJN, 2026, Volume 21, 1
DOI: 10.2147/IJN.S581228

Exploring Nanocarriers as Treatment Modalities for Skin Cancer

Mohammad Adnan, Md. Habban Akhter, Obaid Afzal, Abdulmalik S. A. Altamimi, Irfan Ahmad, Manal A. Alossaimi, Mariusz Jaremko, Abdul-Hamid Emwas, Tanweer Haider and Md. Faheem Haider

Molecules, 2023, 28, 5905
DOI: 10.3390/molecules28155905

Skin Impedance Analysis for Drug Delivery: Integration of Poisson–Boltzmann–Nernst–Planck Model and Ebola Optimisation Algorithm

L Maceal Tony and R.S Shaji

Measurement Science Review, 2025, 25, 347
DOI: 10.2478/msr-2025-0038

Nanocarrier-Based Transdermal Drug Delivery Systems for Dermatological Therapy

Yunxiang Kang, Sunxin Zhang, Guoqi Wang, Ziwei Yan, Guyuan Wu, Lu Tang and Wei Wang

Pharmaceutics, 2024, 16, 1384
DOI: 10.3390/pharmaceutics16111384

Collagen-decorated drug-loaded polycaprolactone microspheres for breast cancer therapy in vitro and in vivo model

Linjie Wang, Siying Huang, Delai Kang, Hui Wu, Lian Zhu, Yunjun Mei, Chengzhi Xu, Juntao Zhang, Benmei Wei and Haibo Wang

International Journal of Biological Macromolecules, 2025, 330, 147982
DOI: 10.1016/j.ijbiomac.2025.147982

Exploring Astaxanthin-loaded Nanoformulations for Skin Targeting: Present Progress and Prospective Directions

Rajwant Kaur, Vimal Arora and Manish Goswami

CDTH, 2025, 20, 1149
DOI: 10.2174/0115748855310234240909083156

Metal–Organic Framework and Biopolymer-Based Composite Hydrogel for Enhanced Encapsulation of Anticancer Drugs: A New Age Transdermal Drug Delivery Vehicle

Hiral Ukani, Nildhara Parsana, Sanjay Mehra, Arvind Kumar, Imran Khan, Mohammed A. Assiri and Naved Malek

ACS Appl. Eng. Mater., 2024, 2, 2583
DOI: 10.1021/acsaenm.4c00508

Breaking boundaries: the advancements in transdermal delivery of antibiotics

Ahlam Zaid Alkilani, Rania Hamed, Batool Musleh and Zaina Sharaire

Drug Delivery, 2024, 31
DOI: 10.1080/10717544.2024.2304251

Transdermal drugs and delivery strategies: History, advances and future prospects

Yefeng Wang, Siwen Wu, Jiyu Chen, Siyi Yang, Chenrui Wu, Qingying Zhao, Heqi Zhang, Kaiting Wei, Jiani Zhang, Rui Zhang and Li Yang

Chinese Chemical Letters, 2025, 112170
DOI: 10.1016/j.cclet.2025.112170

Nano transdermal system combining mitochondria-targeting cerium oxide nanoparticles with all-trans retinoic acid for psoriasis

Wei Wang, Xinyi Xu, Yanling Song, Lan Lan, Jun Wang, Xinchang Xu and Yongzhong Du

Asian Journal of Pharmaceutical Sciences, 2023, 18, 100846
DOI: 10.1016/j.ajps.2023.100846

Topical treatment of skin diseases with bioactive inorganic nanomaterials: Beyond drug delivery

Francesca Corsi, Andrea Pelliccia, Greta Deidda Tarquini, Marta Urbani, Cristina Maria Failla, Enrico Traversa and Lina Ghibelli

Next Materials, 2025, 6, 100401
DOI: 10.1016/j.nxmate.2024.100401

A complete sojourn of recent advancements and applications in transdermal drug delivery systems

Taqdir Singh, Akshita Arora, Kantrol Kumar Sahu, Preeti Patel, Simranjeet Kaur, Shubham Thakur, Ghanshyam Das Gupta, Dilpreet Singh and Balak Das Kurmi

Journal of Drug Delivery Science and Technology, 2024, 102, 106328
DOI: 10.1016/j.jddst.2024.106328

Evaluation of Skin Penetration of Fluorescent Dissolved Formulations Using Confocal Laser Scanning Microscopy

Yoshihiro Oaku, Toshinari Kuwae, Takeshi Misono, Taku Ogura and Akinari Abe

Pharmaceutics, 2025, 17, 1534
DOI: 10.3390/pharmaceutics17121534

Synergistic Strategies of Biomolecular Transport Technologies in Transdermal Healthcare Systems

Jieun Han, Yi‐Jeong Choi and Seung‐Kyun Kang

Adv Healthcare Materials, 2024, 13
DOI: 10.1002/adhm.202401753

Unravelling the in vivo dynamics of liposomes: Insights into biodistribution and cellular membrane interactions

Sharanya Paramshetti, Mohit Angolkar, Sirajunisa Talath, Riyaz Ali M. Osmani, Asha Spandana, Adel Al Fatease, Umme Hani, K.V.R.N.S. Ramesh and Ekta Singh

Life Sciences, 2024, 346, 122616
DOI: 10.1016/j.lfs.2024.122616

Formulation of Microemulsion-Based Gels for Enhanced Topical Administration of Nonsteroidal Anti-Inflammatory Drugs

Muhammad Yasir Siddique, Ahmad Raza Ashraf, Salah Uddin Khan, Muhammad Atif Saleem, Muhammad Ashfaq, Kamran Alam, Ahmed Ahmed Ibrahim and Muhammad Faizan Nazar

Langmuir, 2024, 40, 24174
DOI: 10.1021/acs.langmuir.4c03749

Strong infiltrative HHC36 antimicrobial peptide/silver nanoparticles-loaded carboxymethyl chitosan/sodium alginate hydrogel for acne vulgaris therapy

Hongju Liu, Jiezhao Zhan, Ruibin Lin, Ying Yin and Li Ren

Nanotechnology, 2023, 34, 495101
DOI: 10.1088/1361-6528/acf5f5

Chitosan-collagen composite biomaterials: Advances and insights into properties and biomedical applications

Jinhong Huang, Hongrui Dong, Lefan Li, Lingxue Kong and Zhang Hu

International Journal of Biological Macromolecules, 2025, 320, 146031
DOI: 10.1016/j.ijbiomac.2025.146031

Nanoparticle‐Integrated Transdermal Patches: A Platform for Next‐Generation Drug Delivery

Neethi Mohan, Remya Prabhavathi Amma Neelakandan Nair and Damodharan Narayanasamy

Drug Development Research, 2025, 86
DOI: 10.1002/ddr.70164

Biomimetic Protein Materials for Adjuvant-Free Dermal Penetration

Marianna T. P. Favaro, Eric Voltà-Durán, Julieta M. Sánchez, Elvira Escribano-Ferrer, Vanesa Huaca, Eva Miranda-Tovar, Ugutz Unzueta, Eloi Parladé, Esther Vázquez, Ramon Mangues, Antonio Villaverde and Isolda Casanova

ACS Materials Lett., 2026, 8, 1045
DOI: 10.1021/acsmaterialslett.5c01250

Ameliorating Myocardial Infarction by Concurrent Pyroptosis Suppression and On-Demand Oxygen Production via Functionalized Nanocarrier

Wenwu Zhu, Yao Lu, Bin Zong, Ziyi Chen, Yong Ma, Haoran Wang, Peng Cao and Bing Han

ACS Appl. Mater. Interfaces, 2025, 17, 41626
DOI: 10.1021/acsami.5c01964

Transdermal Drug Delivery Systems: Methods for Enhancing Skin Permeability and Their Evaluation

Elena O. Bakhrushina, Marina M. Shumkova, Yana V. Avdonina, Arsen A. Ananian, Mina Babazadeh, Ghazaleh Pouya, Viktoria V. Grikh, Irina M. Zubareva, Svetlana I. Kosenkova, Ivan I. Krasnyuk and Ivan I. Krasnyuk

Pharmaceutics, 2025, 17, 936
DOI: 10.3390/pharmaceutics17070936

Polymeric microsponges: an emerging prospect in topical delivery of therapeutic agents

Lalit Kumar, Mohit Chadha, Ritesh Rana, Gauree Kukreti, Amit Kumar Kaundal, Vikas Aggarwal and Mohit Vij

International Journal of Polymeric Materials and Polymeric Biomaterials, 2024, 73, 1003
DOI: 10.1080/00914037.2023.2235872

Delivery of nanocarriers with dissolvable microneedles for skin treatments: Approaches and challenges

Amiremad Kheirieh, Amirhossein Abbasi, Bizhan Malaekeh-Nikouei, Shiva Golmohammadzadeh and Seyed Ali Mousavi Shaegh

Journal of Drug Delivery Science and Technology, 2025, 107, 106836
DOI: 10.1016/j.jddst.2025.106836

The future of dermatology: integrating artificial intelligence into clinical practice

Nawaf Almutairi, Bakri Al Agraa and Zainab Mohamed

Int J Res Dermatol, 2025, 11, 208
DOI: 10.18203/issn.2455-4529.IntJResDermatol20250444

Optical Methods for Non-Invasive Determination of Skin Penetration: Current Trends, Advances, Possibilities, Prospects, and Translation into In Vivo Human Studies

Maxim E. Darvin

Pharmaceutics, 2023, 15, 2272
DOI: 10.3390/pharmaceutics15092272

Nanotecnología aplicada a la liberación transdérmica de medicamentos nanoparches, vesículas lipídicas y dendrímeros

Ana Parada-Silgado, Eleine Cabarcas-Lara, Georgeth Rhenals-Perez, Jennyfer Rhenals-Perez, Glicerio León-Mendez and María Osorio-Fortich

Tek. rev. cient., 2025, 25, 71
DOI: 10.25044/25392190.1110

Cyclodextrin Derivatives as Modulators for Enhanced Drug Delivery from Niosome Membrane: A Fluorescence Correlation Spectroscopy and Isothermal Titration Calorimetry Approach

Saurabh Rai, Madhumita Mukherjee, Bijan Kumar Paul and Saptarshi Mukherjee

Langmuir, 2025, 41, 1601
DOI: 10.1021/acs.langmuir.4c03400

Stimuli-responsive drug delivery systems for inflammatory skin conditions

Luna Gade, Ben J. Boyd, Martin Malmsten and Andrea Heinz

Acta Biomaterialia, 2024, 187, 1
DOI: 10.1016/j.actbio.2024.08.037

Characterization of Gold Nanoparticles Synthesized with Zingiber zerumbet Extracts

Wayne C. Liao, Collin S. Liao, Yu-Chen Lin, Ching-Yi Lien and Jose M. G. Martinho

Journal of Chemistry, 2024, 2024, 1
DOI: 10.1155/2024/1358495

Topical delivery of siRNA to psoriatic skin model using high molecular weight chitosan derivatives: In vitro and in vivo studies

André Miguel Martinez Junior, Thalles Fernando Rocha Ruiz, Patrícia Simone Leite Vilamaior, Vera Aparecida de Oliveira Tiera, Sebastião Roberto Taboga and Marcio José Tiera

Drug Deliv. and Transl. Res., 2025, 15, 3199
DOI: 10.1007/s13346-025-01800-4

Exploring efficient therapy for cutaneous neoplasm using gel formulations

Usha D. H. and Keerthy H. S.

Drug Development and Industrial Pharmacy, 2025, 51, 1650
DOI: 10.1080/03639045.2025.2560025

Impact of Drug Hydrophilicity on Transdermal Delivery by Nanoemulsions

Özge Esen Yigit and Alf Lamprecht

Pharmaceutics, 2026, 18, 220
DOI: 10.3390/pharmaceutics18020220

Hyaluronic acid-based reduction responsive nanoparticles for Improved anti-psoriasis effects of traditional Chinese herb monomer oleanolic acid via blocking YAP-AREG axis

Ying Han, Junjie Ren, Yue Su, Linzhu Zhou, Xinyuan Zhu, Zejian Wang, Fei Kong and Guolin Li

J Nanobiotechnol, 2026, 24
DOI: 10.1186/s12951-026-04264-x

Recent advancements in nanoparticle-based topical drug delivery systems for psoriasis treatment

Ritwik Mitra, Dinesh Kumar Sharma, Arnab Ghosh and Sahil Senapati

Journal of Drug Targeting, 2026, 34, 151
DOI: 10.1080/1061186X.2025.2544783

A Nanoliposome Platform Co-Delivery of Hydroxypinacolone Retinoate and Carnosine for Enhanced Epidermal/Dermal Delivery and Multi-Functional Anti-Aging Efficacy

Siyuan Chen, Lihao Gu, Ruili Zhao, Lihua Zhang, Lina Yao, Jingning Shen, Dan Luo, Xi Wang, Dan Chen, Si Zhao, Hong Zhou and Wei Liu

Pharmaceutics, 2026, 18, 454
DOI: 10.3390/pharmaceutics18040454

One‐Step Synthesis of Metal Oxide Nanoparticles Using Cannabidiol: Characterisation and Cytotoxicity Assessment in Human Keratinocyte Cells

Andrea Jess Josiah, Sreejarani Kesavan Pillai, Werner Cordier, Margo Nell, Namrita Lall, Danielle Twilley and Suprakas Sinha Ray

ChemistrySelect, 2024, 9
DOI: 10.1002/slct.202304373

Exploring nanocomposite materials in clinical dermatology: Innovations for treating skin diseases

Sandipan Dasgupta, Subhasundar Maji, Sanjay Dey, Moitreyee Chattopadhyay, Ananya Chanda, Satarupa Acharjee, Kousik Santra and Kazi Asraf Ali

Next Nanotechnology, 2025, 7, 100139
DOI: 10.1016/j.nxnano.2025.100139

Interplay of photobiological stress and chronodermal dysfunction: two-dimensional nanomaterial strategies for barrier restoration in smart cosmetics

Xuexue Pan, Yi Zhao, Weiyuan Huang, Jiayi Wu, Jianrong Liang, Yuanlin Xie, Yanchun Chen and Wenhua Zhao

Arch Dermatol Res, 2025, 317
DOI: 10.1007/s00403-025-04417-2

Investigating the efficacy of mirtazapine-embedded invasomal gel nanocarriers via I-optimal design for management of atopic dermatitis

Tarek M. Ibrahim, Nourhan A. Abdulla and Mai A. Mohamed

Journal of Drug Delivery Science and Technology, 2024, 92, 105395
DOI: 10.1016/j.jddst.2024.105395

Engineered Tissue Models to Decode Host–Microbiota Interactions

Miryam Adelfio, Grace E. Callen, Xuesong He, Bruce J. Paster, Hatice Hasturk and Chiara E. Ghezzi

Advanced Science, 2025, 12
DOI: 10.1002/advs.202417687

Ethosomes as a carrier for transdermal drug delivery system: methodology and recent developments

Karishma Mahajan, Poonam Sharma, Vikrant Abbot and Kalpana Chauhan

Journal of Liposome Research, 2024, 34, 697
DOI: 10.1080/08982104.2024.2339896

Chitosan-gold nanoparticles: A trend of skin permeation enhancement effect in animal and human skin model

Kanokwan Singpanna, Phuvamin Suriyaamporn, Chaiyakarn Pornpitchanarong, Tanasait Ngawhirunpat, S. Kevin Li and Praneet Opanasopit

Journal of Drug Delivery Science and Technology, 2025, 105, 106598
DOI: 10.1016/j.jddst.2025.106598

Plant-Based Nanovesicular Gel Formulations Applied to Skin for Ameliorating the Anti-Inflammatory Efficiency

Hanan Abdelmawgoud Atia, Mona M. Shahien, Somaia Ibrahim, Enas Haridy Ahmed, Hemat A. Elariny and Marwa H. Abdallah

Gels, 2024, 10, 525
DOI: 10.3390/gels10080525

Nanostructured Lipid Carrier-Gels for Wound Healing: A Narrative Review of Formulation Strategies, Mechanisms, and Translational Potential

Ayatulloh Alquraisy, Khoirunnisa Ramadhani, Ahmed Mohammed, Gofarana Wilar, Wadah Osman, Khaled Elamin and Nasrul Wathoni

NSA, 2026, Volume 19, 1
DOI: 10.2147/NSA.S585159

Therapeutic potential of spray-based delivery system for the treatment of dermatological disorders: clinical insights and formulation advances

Devesh Kumar, Prachee Nirmale, Suresh Babu Kondaveeti, Mohit Agrawal, Thakur Gurjeet Singh, Ankit Awasthi and Mohit Kumar

International Journal of Pharmaceutics, 2026, 695, 126766
DOI: 10.1016/j.ijpharm.2026.126766

A Review on the Mechanisms, Applications, and Clinical Trials of Advanced Technologies in the Transdermal Drug Delivery System

Afina Faqkira Abdul Aziz, Yun Qing Beh, Iffah Izzati Farahiyah, Soraya Syahrul Azmir, Phei Er Kee, A.B.M. Helal Uddin and Kai Bin Liew

CPB, 2025, 26, 1971
DOI: 10.2174/0113892010318519240813053106

Chitosan and its amphiphilic derivative nanoparticles loaded with Minoxidil for induction of hair growth: In vitro and in vivo evaluation

Amin Haghighat Naeini, Kosar Mahdavipour, Ali Rastegari, Mehdi Aghsami, Hamed Montazeri, Homa Faghihi and Zohreh Mohammadi

International Journal of Biological Macromolecules, 2024, 259, 129122
DOI: 10.1016/j.ijbiomac.2023.129122

Effect of cosmetic ingredients as functional agents: synergistic action of electroporation and sonophoresis in clinical efficacy

Tae-Rin Kwon, Jungwook Kim, Soo Min Kim, Hyoung Jun Kim, Jungkwan Lee and Kwang Ho Yoo

Medical Lasers, 2025, 14, 16
DOI: 10.25289/ML.25.009

Adsorption of Dacarbazine as Anticancer Drug on Si60, C60, B30N30, Sc-Si60, Sc-C60, Sc-B30N30 Nanocages

Junjuan Zhang, Xiangtao Yu, Jing Wang and Xiangwen Yao

Silicon, 2024, 16, 5563
DOI: 10.1007/s12633-024-03099-1

Production and comprehensive characterization of PVA/chitosan transdermal composite mats loaded with bioactive curcumin; evaluation of its release kinetics, antioxidant, antimicrobial, and biocompatibility features

Fatih Ciftci, Ali Can Özarslan and Nilüfer Evcimen Duygulu

J of Applied Polymer Sci, 2024, 141
DOI: 10.1002/app.55874

Review on nanogels and their applications on dermal therapy

Nandipha L Botha, Paul Mushonga and Martin O Onani

Polymers and Polymer Composites, 2023, 31
DOI: 10.1177/09673911231192816

Rapid dissolving microneedle patch integrated with benidipine-loaded nanotransfersomes for transdermal drug delivery: optimization, characterizations, and preclinical bioavailability assessment

Khater AL-Japairai, Samah Hamed Almurisi, Fawaz Alheibshy, Nadiya Abdul-Halim and Syed Mahmood

Drug Deliv. and Transl. Res., 2026, 16, 1629
DOI: 10.1007/s13346-025-01976-9

Ethosomal Nanocarriers: A Breakthrough in Transdermal and Targeted Drug Delivery

Karikalachsozhan Prakash Raj and Govindaraj Sabarees

Biomedical Materials & Devices, 2026
DOI: 10.1007/s44174-025-00576-y

Angiogenic biomaterials for diabetic wound healing: A review

Asad Ullah, Shakera Mohsin, Mohammad Nawshad, Ken Ninez Nurpramesti Prinindya, Abdulla al Mamun, Maimoona Bukhari, Faizan Haider, Elsadig Mahdi and Anwarul Hasan

Materials Today Communications, 2026, 50, 114508
DOI: 10.1016/j.mtcomm.2025.114508

Bioinspired hydrogels for infectious and diabetic wound healing: Therapeutic strategies and innovations

Sadeed Ahmad, Mishal Fatima, Muhammad Zulqarnain, Yasir Javed, Muhammad Khawar Abbas and Naveed Akhtar Shad

Nanomedicine: Nanotechnology, Biology and Medicine, 2026, 74, 102938
DOI: 10.1016/j.nano.2026.102938

Assessing the potential of metallic nanocarriers as theranostics for psoriasis management: a comprehensive review

Rupali Verma, Neha Jain, Shreya Kaul and Manisha Pandey

Appl Nanosci, 2025, 15
DOI: 10.1007/s13204-025-03101-1

Antimicrobial Nanocomposites from Chitosan and Squash Synthesized Nano‐Selenium Eradicate Skin Pathogens

Esraa M. Meshref, Amira A. E.‐D. Omar, Shaaban H. Moussa, Amira H. Alabdalall, Mohammed S. Al‐Saggaf, Adel I. Alalawy, Fahad M. Almutairi, Hend A. Gad and Ahmed A. Tayel

ChemistrySelect, 2024, 9
DOI: 10.1002/slct.202400881

Investigating stimuli-responsive liposomes for cutaneous applications: a guide to stimuli recognition and characterization

Marta Miotke-Wasilczyk and Andrea Heinz

International Journal of Pharmaceutics, 2026, 689, 126519
DOI: 10.1016/j.ijpharm.2025.126519

Fibroblast-Targeted Nanodelivery Systems: Mechanisms of Collagen Remodeling Regulation and Novel Strategies for Scar Repair

Junshan Lan, Zhipeng Teng, Qian Huang, Fang Qin, Yibin Zheng, Yuting Liu, Yilin Chang, Xing Zhou, Xiaohui Li, Wenwu Wan, Lu Wang and Jie Lou

Pharmaceutics, 2026, 18, 172
DOI: 10.3390/pharmaceutics18020172

Application of nanotechnology in anti-aging cosmetics: advantages, challenges, and prospects

Xuexue Pan, Zhida Zhong, Xiaoxiao Hu, Jingyi Wu, Weiyuan Huang, Wenkai Li, Yi Zhao, Yuanlin Xie, Yawei Huang, Jianrong Liang, Jiayi Wu, Rongyue Huang, Jinjie Xie, Meiyu Wu, Rong Hu, Yonggan Fang, Lu Zhang and Jun Wang

Polym. Bull., 2025, 82, 8635
DOI: 10.1007/s00289-025-05903-3

Cinnamomum burmannii Leaves-Derived Carbon Dots Promote Angiogenesis and Stimulate Hair Follicle Regeneration by Reshaping the Microenvironment of Hair Follicles

Shunxing Peng, Xinyu Cai, Wenjun Zhang, Pengzhen Li, Xiaodan Fan, Liming Fang, Penghui Fan and Jianyu Su

ACS Appl. Mater. Interfaces, 2026, 18, 12923
DOI: 10.1021/acsami.5c21964

Strategies to Improve the Transdermal Delivery of Poorly Water-Soluble Non-Steroidal Anti-Inflammatory Drugs

Alexandra Balmanno, James R. Falconer, Halley G. Ravuri and Paul C. Mills

Pharmaceutics, 2024, 16, 675
DOI: 10.3390/pharmaceutics16050675

Topical delivery of meropenem via spanlastic carbopol gel: in-vitro studies and in-vivo application in pressure ulcers

Shadwa Abdelfattah, Fatma Mohamed Mady, Hatem A. Sarhan, Hazim O. Khalifa, Hamada Hashem, Hesham Hassan, Abdullah Alkhammash, Safy Hadiya, Reham Ali Ibrahem and Milad Reda Qelliny

Front. Pharmacol., 2025, 16
DOI: 10.3389/fphar.2025.1672677

Polymeric Nanocarriers for Transdermal Drug Delivery: A Systematic Review and Meta‐Analysis

Arvind Raghav and Vaibhav Rastogi

Macromolecular Symposia, 2026
DOI: 10.1002/masy.70278

Multi-scale delivery dynamics of tetrahedral framework nucleic acids: From organ accumulation to subcellular targeting and precision engineering strategies

Wen Chen, Hao Wang, Qiang Sun, Shaojingya Gao, Yunfeng Lin, Yun Wang and Xiaoxiao Cai

Chinese Chemical Letters, 2026, 37, 111396
DOI: 10.1016/j.cclet.2025.111396

Nanomaterial-Enhanced Microneedles: Emerging Therapies for Diabetes and Obesity

Mehrnaz Abbasi, Divine Afunu Boka and Hannah DeLoit

Pharmaceutics, 2024, 16, 1344
DOI: 10.3390/pharmaceutics16101344

A review on exploring the emerging role of novel transdermal gel drug delivery systems for skin diseases

Prince Nikhil Rathore, Anirban Pal, Sakshi Pandey, Sayani Maji and Alpana Ram

Next Research, 2025, 2, 100373
DOI: 10.1016/j.nexres.2025.100373

Feeding the Body Through the Skin: Ethosomes and Transethosomes as a New Topical Delivery System for Bioactive Compounds

Elisabetta Esposito, Alessandra Pecorelli, Francesca Ferrara, Mary Ann Lila and Giuseppe Valacchi

Annual Review of Food Science and Technology, 2024, 15, 53
DOI: 10.1146/annurev-food-072023-034528

Skin Permeation of Hydrophilic Middle-to-High Molecular Weight Model Drugs from Decanoic Acid/Arginine Supramolecular Hydrogels

Ryuichiro Mochizuki, Kohsuke Shibasaki, Kaname Hashizaki, Makiko Fujii and Hiroyuki Taguchi

Biological & Pharmaceutical Bulletin, 2025, 48, 733
DOI: 10.1248/bpb.b24-00770

Nanotechnology-Based Strategies for Hair Regeneration: Mechanistic Insights and Translational Perspectives for Androgenetic Alopecia

Wenran Zhou and Rongcheng Han

Biomedicines, 2026, 14, 521
DOI: 10.3390/biomedicines14030521