Thymoquinone chemically conjugated to doxorubicin: antitumor activity and subcellular localization

Ismail Sami Mahmoud, Hamdi Nsairat, Shorouq Alsotari, Areej Jaber, Ezaldeen Esawi, Hiba Abdelnabi, Majed Al Holi, El Soubani Fatima, Walhan Alshaer and Fadwa Odeh

RSC Adv., 2025, 15, 38176
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Dietary tangeretin improved antibiotic-associated diarrhea in mice by enhancing the intestinal barrier function, regulating the gut microbiota, and metabolic homeostasis

Bin Chen, Xun Yang, Minmin Zhan, Yilu Chen, Jingyi Xu, Jie Xiao, Hang Xiao and Mingyue Song

Food Funct., 2023, 14, 10731
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Dietary black cumin (Nigella sativa) improved hemato-biochemical, oxidative stress, gene expression, and immunological response of Nile tilapia (Oreochromis niloticus) infected by Burkholderia cepacia

Heba H. Mahboub, Hassnaa Mahmoud Elsheshtawy, Nagwa I. Sheraiba, Esra.M. Fahmy, Shimaa R. masoud, Eman A.A. Mohamed, Noha S. Abdelnaeim, Dalia Ibrahim Mohamed, Tamer Ahmed Ismail and Shaimaa A.A. Ahmed

Aquaculture Reports, 2022, 22, 100943
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Application Potential of Plant-Derived Medicines in Prevention and Treatment of Platinum-Induced Peripheral Neurotoxicity

Xiaowei Xu, Liqun Jia, Xiaoran Ma, Huayao Li and Changgang Sun

Front. Pharmacol., 2022, 12
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Antioxidant Potential Evaluation at Various Stages of Black Cumin Oil Production

Dobrochna Rabiej-Kozioł and Aleksandra Szydłowska-Czerniak

Foods, 2024, 13, 3518
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Water-soluble caffeic acid-dopamine acid-base complex exhibits enhanced bactericidal, antioxidant, and anticancer properties

Hemanjali Mude, Pranay Amruth Maroju, Aniket Balapure, Ramakrishnan Ganesan and Jayati Ray Dutta

Food Chemistry, 2022, 374, 131830
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Thymoquinone: A Review on its Pharmacological Importance, and its Association with Oxidative Stress, COVID-19, and Radiotherapy

Seyithan Taysi, Firas Shawqi Algburi, Zaid Rakan Mohammed, Omeed Akbar Ali and Muhammed Enes Taysi

MRMC, 2022, 22, 1847
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The alteration of brain function in overweight/obese individuals and the neurological benefit of thymoquinone: uncovering molecular mechanisms

Mostafa D. Mostafa, Magda A. El-Komy, Maggie E. Amer, Azza I. Othman and Mohamed A. El-Missiry

Metab Brain Dis, 2026, 41
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Molecular Hybridization as a Strategy for Developing Artemisinin-Derived Anticancer Candidates

Elena Marchesi, Daniela Perrone and Maria Luisa Navacchia

Pharmaceutics, 2023, 15, 2185
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The Role of Plant Extracts in the Perspective of Oral Squamous Cell Carcinoma Treatment

Kamila Alibekovna Saypulaeva, Saniyat Zubairugadjievna Alieva, Gindi Garunovna Gazieva, Albina Ruslanovna Israfilova, Asiyat Shakhbanovna Gusenova, Aminat Ruslanovna Musieva, Arevik Simenovna Anesyan, Elizaveta Evgenyevna Kiseleva, Tamara Igorevna Tsibirova and Sabina Alievna Uzhbanokova

Asian J Periodontics Orthod, 2026, 6, 59
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Thymoquinone-conjugated liposomes improve cytotoxic and proapoptotic effects against hepatocellular cancer by altering the EGFR/ERK/MEK signaling axis

Shaymaa A. Abdulmalek, Fatma A. Mahmoud, Doaa Awad, Abdulrahman M. Saleh, Ayman I. Elkady, Doaa A. Ghareeb and Mahmoud Balbaa

Discov Onc, 2025, 16
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Dietary intervention of ginger and black seed oils boosted hematology, biochemical profile, and antioxidant-immune responses in Oreochromis niloticus challenged with Aeromonas veronii

Shaimaa E. Ibrahim, Fatma M. Abdelhamid, Elsayed Nabeeh Abou ElGheit, Mohamed A.H. El-kady, Gehad E. Elshopakey and Engy F. Risha

Aquaculture, 2025, 603, 742398
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Development and Optimization of Methylcellulose-Based Nanoemulgel Loaded with Nigella sativa Oil for Oral Health Management: Quadratic Model Approach

Muhammad H. Sultan, Shamama Javed, Osama Ali Madkhali, Mohammad Intakhab Alam, Yosif Almoshari, Mohammad Ali Bakkari, Durgaramani Sivadasan, Ahmad Salawi, Ameena Jabeen and Waquar Ahsan

Molecules, 2022, 27, 1796
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Biological Potential of the Main Component, Thymoquinone, of Nigella sativa in Pulp Therapy—In Vitro Study

Rana A. Alamoudi, Soha A. Alamoudi and Ruaa A. Alamoudi

Life, 2022, 12, 1434
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Advances in the Role and Mechanisms of Essential Oils and Plant Extracts as Natural Preservatives to Extend the Postharvest Shelf Life of Edible Mushrooms

Yuxi Guo, Xuefeng Chen, Pin Gong, Ruotong Wang, Aoyang Han, Zhenfang Deng, Zhuoya Qi, Hui Long, Jiating Wang, Wenbo Yao, Wenjuan Yang, Jing Wang and Nan Li

Foods, 2023, 12, 801
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Insights into the Sources, Structure, and Action Mechanisms of Quinones on Diabetes: A Review

Tingting Zhang, Mingyue Li, Jingyang Lu, Jia Wang, Min Zhang, Pharkphoom Panichayupakaranant and Haixia Chen

Molecules, 2025, 30, 665
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Thymoquinone attenuates inflammation in C. Albicans keratitis by activating Nrf2/HO-1 signaling pathway and reducing fungal load

Hua Yao, Liting Hu, Nan Jiang, Lin Gao, Runfa Jiang, Xueqing Liu, Wendan Zheng and Guiqiu Zhao

Cytokine, 2023, 172, 156375
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Stereological and biochemical effects of thymoquinone on ovarian tissue toxicity induced by silver nanoparticles in NMRI mice: An experimental study

Seyed Mohammad Ali Shariatzadeh, Fatemeh Salmani, Hossein Moghanlo and Monireh Mahmoodi

IJRM, 2024, 22, 553
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Ethnomedicinal Uses, Phytochemistry, and Therapeutic Potentials of Litsea glutinosa (Lour.) C. B. Robinson: A Literature-Based Review

Sarmin Jamaddar, António Raposo, Chandan Sarkar, Uttam Kumar Roy, Isaac Moura Araújo, Henrique Douglas Melo Coutinho, Ali Saleh Alkhoshaiban, Hmidan A. Alturki, Ariana Saraiva, Conrado Carrascosa and Muhammad Torequl Islam

Pharmaceuticals, 2022, 16, 3
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Analysis of Pharmacological Properties of Nigella sativa L. Bioactive Compounds and Their Therapeutic Relevance in the Management of Type 2 Diabetes Mellitus

Monica Tabita Morar (Romocea), Annamaria Pallag, Cristina Burlou-Nagy (Fati), Laura Grațiela Vicaș, Ioana Lavinia Dejeu, Tünde Horvath, Diana Bei and Cosmin Vesa

Life, 2025, 15, 1681
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Brazilin: An updated literature-based review on its promising therapeutic approaches and toxicological studies

Sarmin Jamaddar, Chandan Sarkar, Shamima Akter, Mohammad S. Mubarak, Heba A.S. El-Nashar, Mohamed El-Shazly and Muhammad Torequl Islam

South African Journal of Botany, 2023, 158, 118
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Potential Therapeutic Efficacy of Ferulic Acid and Its Derivatives in the Management of Cancers: A Comprehensive Analysis With Mechanistic Insight

Shakil Ahmmed, Md. Shimul Bhuia, Raihan Chowdhury, Md. Hanif Munshi, Tanzila Akter Eity, Hossam Kamli, Muhammad Torequl Islam and Zheng-Fei Yan

International Journal of Food Science, 2025, 2025
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Dietary spirulina and black cumin supplementation mitigate extreme warm temperature stress in Nile tilapia, Oreochromis niloticus

Sumaiya Binte Ayesha, Md Jakiul Islam, Most. Shammi Akter Mimi, Mst. Sabrina Akter Sheuly, Tasnia Islam Auditi, Md Kabir Hossain, Kizar Ahmed Sumon, Md Shahjahan, Md Shah Alam and Harunur Rashid

Aquaculture and Fisheries, 2026
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Thymoquinone alleviates myocardial ischemia/reperfusion injury by stabilizing mitochondria-associated membrane homeostasis via targeting ATAD3A

Zeyu Li, Suiqing Huang, Li Luo, Jingxuan Zhang, Ou Hu, Zhongkai Wu and Peiqing Liu

Phytomedicine, 2025, 143, 156914
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Recent advances on Nigella sativa – A promising herb: Antihypertensive properties, thimoquinone nanoformulations, and health applications

Vinay Basavegowda Raghavendra, Niju Sagar, Lekhana Mylimane Kusha, K.L. Krishna, Minaxi Sharma, Kandi Sridhar and Rachitha Puttasiddaiah

Pharmacological Research - Natural Products, 2024, 3, 100052
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Thymoquinone: Review of Its Potential in the Treatment of Neurological Diseases

Faheem Hyder Pottoo, Abdallah Mohammad Ibrahim, Ali Alammar, Rida Alsinan, Mahdi Aleid, Ali Alshehhi, Muruj Alshehri, Supriya Mishra and Noora Alhajri

Pharmaceuticals, 2022, 15, 408
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Protective effect of thymoquinone on glycation of human myoglobin induced by d-ribose

Jing-Jing Liu, Zhan-Yi Wang, Bin-Bin Jiang, Shu-Qin Gao and Ying-Wu Lin

International Journal of Biological Macromolecules, 2023, 253, 127016
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Effects of Dietary Thymoquinone Inclusion on Antioxidative, Oxidative, Pro-Inflammatory Responses, Semen Attributes and Testicular Changes in Heat-Stressed Rabbit Bucks

Maged A. AlGaradi, Ramya A. Sindi, Naif Al-Gabrif, Mohamed E. Abd El-Hack and Sameh A. Abdelnour

Annals of Animal Science, 2024, 24, 109
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GC–MS analysis, and evaluation of protective effect of Piper chaba stem bark against paracetamol-induced liver damage in Sprague-Dawley rats: Possible defensive mechanism by targeting CYP2E1 enzyme through in silico study

Chandan Sarkar, Milon Mondal, Khattab Al-Khafaji, Dina M. El-Kersh, Sarmin Jamaddar, Pranta Ray, Uttam Kumar Roy, Mirola Afroze, Md. Moniruzzaman, Mala Khan, Umma Hafsa Asha, Abul Bashar Ripon Khalipha, Edna Mori, Bruna Caroline Gonçalves Vasconcelos de Lacerda, Isaac Moura Araújo, Henrique Douglas Melo Coutinho, Manik Chandra Shill and Muhammad Torequl Islam

Life Sciences, 2022, 309, 121044
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Antioxidant Properties of Thymoquinone, Thymohydroquinone and Black Cumin (Nigella sativa L.) Seed Oil: Scavenging of Superoxide Radical Studied Using Cyclic Voltammetry, DFT and Single Crystal X-ray Diffraction

Raiyan Sakib, Francesco Caruso, Sandjida Aktar, Stuart Belli, Sarjit Kaur, Melissa Hernandez and Miriam Rossi

Antioxidants, 2023, 12, 607
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Protective effect of thymoquinone nanoemulsion in reducing the cardiotoxic effect of 5‐fluorouracil in rats

Bardia Karim, Motahare Arabameri, Fatemeh Alimoradi, Razieh Mansoori, Ali A. Moghadamnia, Sohrab Kazemi and Seyed M. Hosseini

Drug Development Research, 2024, 85
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Investigating the strengthening effect of Nigella sativa seed extract and Er,Cr:YSGG laser on artificially demineralized dentin: In Vitro study

Sherif Elsayed, Doaa M. Sadony, Ramadan N. Elshaer, Mohamed M. Kandil and Hadeel Farouk

Laser Dent Sci, 2026, 10
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Efficacy of Thymoquinone and Hesperidin in Attenuating Cardiotoxicity from 5-Fluorouracil: Insights from In Vivo and In Silico Studies

Juveriya Farooq, Rokeya Sultana, Jainey P. James, Zakiya Fathima C, Ali F. Almutairy and Abubakar Siddique Mustafa Hussain

Toxics, 2024, 12, 688
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Mechanism of the antidiabetic action of Nigella sativa and Thymoquinone: a review

Arslan Shaukat, Arsalan Zaidi, Haseeb Anwar and Nadeem Kizilbash

Front. Nutr., 2023, 10
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Thymoquinone protects thioacetamide‐induced chronic liver injury by inhibiting TGF‐β1/Smad3 axis in rats

Subramanian Raghunandhakumar, Devaraj Ezhilarasan and Karthik Shree Harini

J Biochem & Molecular Tox, 2024, 38
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Thymoquinone controlled obesity and invigorated cognitive and memory performance in rats consuming a high-fat diet via modulating oxidative stress, inflammation and apoptosis

Mostafa D. Mostafa, Maggie E. Amer, Magda A. ElKomy, Azza I. Othman and Mohamed A. El‑Missiry

Sci Rep, 2025, 15
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